Molecular Anatomic Pathology

The Molecular Anatomic Pathology Laboratory in the Department of Pathology and Laboratory Medicine in the University of Kentucky offers a wide range of tests for specific genetic abnormalities in cancer. Our laboratory is fully CLIA-compliant and certified by the College of American Pathologists. In addition to clinical testing, we also offer these tests for research projects (contact the Director for additional information, click on the Molecular Anatomic Pathology Staff link to the right).

genetic event test type main target cancer(s)
1p/19q codeletion in situ hybridization brain (glioma)
ALK overexpression immunohistochemistry lung
ALK rearrangement in situ hybridization lung
BRAF V600E pyrosequencing thyroid cancer & melanoma
DNA mismatch repair enzyme loss immunohistochemistry colorectal
EGFR amplification in situ hybridization brain (glioma)
EWS rearrangement in situ hybridization sarcoma
HER2 amplification in situ hybridization breast & upper gastrointestinal
IDH1/2 mutations pyrosequencing brain (glioma)
KRAS mutation Sanger sequencing lung, colorectal
MDM2 amplification in situ hybridization sarcoma
MGMT promoter methylation pyrosequencing brain (glioma)
MYC rearrangement in situ hybridization lymphoma
SYT rearrangement in situ hybridization sarcoma

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Please send testing requests to:

Patricia Compton (email:
Department of Pathology and Laboratory Medicine
University of Kentucky
800 Rose Street
Lexington, KY 40536

Phone: 859-323-5425
Fax: 859-323-2094

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