Janna Neltner, M.D.

Bio / Education: 

-Bachelor of Science, Chemistry, University of Kentucky, 1997-2001
-MD, University of Kentucky College of Medicine, 2001-2006
-Post-sophomore student fellowship in Pathology, 2003-2004
-AP/CP residency, University of Kentucky Department of Pathology, 2006-2010
-Neuropathology fellowship, University of Kentucky and Sanders-Brown Center on Aging, 2010-2012

Board Certification
-Anatomic Pathology
-Clinical Pathology

Clinical Specialties
-General surgical and autopsy pathology
-Surgical and autopsy neuropathology
-Pathology of neurodegenerative diseases

Other Activities
-Associate Residency Program Director

Research Description: 

- Pathologic examination of neurodegenerative diseases, including Alzheimer's disease, synucleinopathies, and hippocampal sclerosis (of aging).
- The use of digital image analysis for quantification of findings in neurodegenerative and tumor processes.

PubMed Publications: 

  • Nelson, P.T.;Trojanowski, J.Q.;Abner, E.L.;Al-Janabi, O.M.;Jicha, G.A.;Schmitt, F.A.;Smith, C.D.;Fardo, D.W.;Wang, W.X.;Kryscio, R.J.;Neltner, J.H.;Kukull, W.A.;Cykowski, M.D.;Van Eldik, L.J.;Ighodaro, E.T. ""New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)." Journal of neuropathology and experimental neurology 75, 6 (2016): 482-98. [PubMed Link] | [ Full text ]
  • Ighodaro, E.T.;Abner, E.L.;Fardo, D.W.;Lin, A.L.;Katsumata, Y.;Schmitt, F.A.;Kryscio, R.J.;Jicha, G.A.;Neltner, J.H.;Monsell, S.E.;Kukull, W.A.;Moser, D.K.;Appiah, F.;Bachstetter, A.D.;Van Eldik, L.J.;Alzheimer's Disease Neuroimaging Initiative, (A.D.N.I.);Nelson, P.T. "Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2016): [PubMed Link] | [ Full text ]
  • Neltner, J.H.;Abner, E.L.;Jicha, G.A.;Schmitt, F.A.;Patel, E.;Poon, L.W.;Marla, G.;Green, R.C.;Davey, A.;Johnson, M.A.;Jazwinski, S.M.;Kim, S.;Davis, D.;Woodard, J.L.;Kryscio, R.J.;Van Eldik, L.J.;Nelson, P.T. "Brain pathologies in extreme old age." Neurobiology of aging 37, (2016): 1-11. [PubMed Link] | [ Full text ]
  • Yu, T.;Chen, X.;Zhang, W.;Liu, J.;Avdiushko, R.;Napier, D.L.;Liu, A.X.;Neltner, J.M.;Wang, C.;Cohen, D.;Liu, C. "KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer." Cell death and differentiation 23, 2 (2016): 207-15. [PubMed Link] | [ Full text ]
  • Bachstetter, A.D.;Van Eldik, L.J.;Schmitt, F.A.;Neltner, J.H.;Ighodaro, E.T.;Webster, S.J.;Patel, E.;Abner, E.L.;Kryscio, R.J.;Nelson, P.T. "Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging." Acta neuropathologica communications 3, (2015): 32. [PubMed Link] | [ Full text ]
  • Hance, J.M.;Harris, J.W.;Neltner, J.;Vilchez, V.;Tzeng, C.W.;Maynard, E.;Gedaly, R.;Shah, M.B. "Hepatobiliary mucinous cystadenoma resulting in biliary obstruction." The American surgeon 81, 6 (2015): E238-9. [PubMed Link] | [ Full text ]
  • Hensley, P.;Hilal, T.;Neltner, J.;Kumar, B. "Maintaining sharp focus on a grainy film: miliary pattern in an elderly woman with acute respiratory failure." BMJ case reports 2015, (2015): [PubMed Link] | [ Full text ]
  • Ighodaro, E.T.;Jicha, G.A.;Schmitt, F.A.;Neltner, J.H.;Abner, E.L.;Kryscio, R.J.;Smith, C.D.;Duplessis, T.;Anderson, S.;Patel, E.;Bachstetter, A.;Van Eldik, L.J.;Nelson, P.T. "Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature." Journal of neuropathology and experimental neurology 74, 7 (2015): 642-52. [PubMed Link] | [ Full text ]
  • Fiore, L.S.;Ganguly, S.S.;Sledziona, J.;Cibull, M.L.;Wang, C.;Richards, D.L.;Neltner, J.M.;Beach, C.;McCorkle, J.R.;Kaetzel, D.M.;Plattner, R. "c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer." Oncogene 33, 36 (2014): 4508-20. [PubMed Link] | [ Full text ]
  • Berger, J.R.;Neltner, J.;Smith, C.;Cambi, F. "Posterior reversible encephalopathy syndrome masquerading as progressive multifocal leukoencephalopathy in rituximab treated neuromyelitis optica." Multiple sclerosis and related disorders 3, 6 (2014): 728-31. [PubMed Link] | [ Full text ]
  • Zaytseva, Y.Y.;Elliott, V.A.;Rychahou, P.;Mustain, W.C.;Kim, J.T.;Valentino, J.;Gao, T.;O'Connor, K.L.;Neltner, J.M.;Lee, E.Y.;Weiss, H.L.;Evers, B.M. "Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer." Carcinogenesis 35, 6 (2014): 1341-51. [PubMed Link] | [ Full text ]
  • Neltner, J.H.;Abner, E.L.;Baker, S.;Schmitt, F.A.;Kryscio, R.J.;Jicha, G.A.;Smith, C.D.;Hammack, E.;Kukull, W.A.;Brenowitz, W.D.;Van Eldik, L.J.;Nelson, P.T. "Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing." Brain : a journal of neurology 137, Pt 1 (2014): 255-67. [PubMed Link] | [ Full text ]
  • Gilbert, M.R.;Liu, Y.;Neltner, J.;Pu, H.;Morris, A.;Sunkara, M.;Pittman, T.;Kyprianou, N.;Horbinski, C. "Autophagy and oxidative stress in gliomas with IDH1 mutations." Acta neuropathologica 127, 2 (2014): 221-33. [PubMed Link] | [ Full text ]
  • Wang, W.X.;Danaher, R.J.;Miller, C.S.;Berger, J.R.;Nubia, V.G.;Wilfred, B.S.;Neltner, J.H.;Norris, C.M.;Nelson, P.T. "Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells." Genomics, proteomics & bioinformatics 12, 1 (2014): 19-30. [PubMed Link] | [ Full text ]
  • Scheff, S.W.;Neltner, J.H.;Nelson, P.T. "Is synaptic loss a unique hallmark of Alzheimer's disease?" Biochemical pharmacology 88, 4 (2014): 517-28. [PubMed Link] | [ Full text ]
  • Nelson, P.T.;Estus, S.;Abner, E.L.;Parikh, I.;Malik, M.;Neltner, J.H.;Ighodaro, E.;Wang, W.X.;Wilfred, B.R.;Wang, L.S.;Kukull, W.A.;Nandakumar, K.;Farman, M.L.;Poon, W.W.;Corrada, M.M.;Kawas, C.H.;Cribbs, D.H.;Bennett, D.A.;Schneider, J.A.;Larson, E.B.;Crane, P.K.;Valladares, O.;Schmitt, F.A.;Kryscio, R.J.;Jicha, G.A.;Smith, C.D.;Scheff, S.W.;Sonnen, J.A.;Haines, J.L.;Pericak-Vance, M.A.;Mayeux, R.;Farrer, L.A.;Van Eldik, L.J.;Horbinski, C.;Green, R.C.;Gearing, M.;Poon, L.W.;Kramer, P.L.;Woltjer, R.L.;Montine, T.J.;Partch, A.B.;Rajic, A.J.;Richmire, K.;Monsell, S.E.;Alzheimer’ Disease Genetic, C.;Schellenberg, G.D.;Fardo, D.W. "ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology." Acta neuropathologica 127, 6 (2014): 825-43. [PubMed Link] | [ Full text ]
  • Attems, J.;Neltner, J.H.;Nelson, P.T. "Quantitative neuropathological assessment to investigate cerebral multi-morbidity." Alzheimer's research & therapy 6, 9 (2014): 85. [PubMed Link] | [ Full text ]
  • Nelson, P.T.;Smith, C.D.;Abner, E.L.;Wilfred, B.J.;Wang, W.X.;Neltner, J.H.;Baker, M.;Fardo, D.W.;Kryscio, R.J.;Scheff, S.W.;Jicha, G.A.;Jellinger, K.A.;Van Eldik, L.J.;Schmitt, F.A. "Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease." Acta neuropathologica 126, 2 (2013): 161-77. [PubMed Link] | [ Full text ]
  • Bachstetter, A.D.;Norris, C.M.;Sompol, P.;Wilcock, D.M.;Goulding, D.;Neltner, J.H.;St Clair, D.;Watterson, D.M.;Van Eldik, L.J. "Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 30 (2012): 10201-10. [PubMed Link] | [ Full text ]
  • Neltner, J.H.;Abner, E.L.;Schmitt, F.A.;Denison, S.K.;Anderson, S.;Patel, E.;Nelson, P.T. "Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes." Journal of neuropathology and experimental neurology 71, 12 (2012): 1075-85. [PubMed Link] | [ Full text ]
  • Nelson, P.T.;Schmitt, F.A.;Lin, Y.;Abner, E.L.;Jicha, G.A.;Patel, E.;Thomason, P.C.;Neltner, J.H.;Smith, C.D.;Santacruz, K.S.;Sonnen, J.A.;Poon, L.W.;Gearing, M.;Green, R.C.;Woodard, J.L.;Van Eldik, L.J.;Kryscio, R.J. "Hippocampal sclerosis in advanced age: clinical and pathological features." Brain : a journal of neurology 134, Pt 5 (2011): 1506-18. [PubMed Link] | [ Full text ]
  • Nelson, P.T.;Head, E.;Schmitt, F.A.;Davis, P.R.;Neltner, J.H.;Jicha, G.A.;Abner, E.L.;Smith, C.D.;Van Eldik, L.J.;Kryscio, R.J.;Scheff, S.W. "Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies." Acta neuropathologica 121, 5 (2011): 571-87. [PubMed Link] | [ Full text ]
  • Abner, E.L.;Kryscio, R.J.;Schmitt, F.A.;Santacruz, K.S.;Jicha, G.A.;Lin, Y.;Neltner, J.M.;Smith, C.D.;Van Eldik, L.J.;Nelson, P.T. ""End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?" Journal of Alzheimer's disease : JAD 25, 3 (2011): 445-53. [PubMed Link] | [ Full text ]