Janna Neltner, MD | Pathology & Laboratory Medicine

Janna Neltner, MD

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jmhack0@email.uky.edu
MS 155

Position(s):

Assistant Professor

Director - Pathology Residency Program

Affiliation(s):

Pathology & Laboratory Medicine

Interests / Specialties:

Anatomical and Clinical Pathology and Neuropathology

Bio / Education:

University of Kentucky - Doctor of Medicine
University of Kentucky - Residency (AP/CP)
University of Kentucky - Fellowship (Neuropathology)

Research Description:

- Pathologic examination of neurodegenerative diseases, including Alzheimer's disease, synucleinopathies, and hippocampal sclerosis (of aging).
- The use of digital image analysis for quantification of findings in neurodegenerative and tumor processes.

PubMed Publications:

Tulloch, J.;Leong, L.;Chen, S.;Keene, CD ;Millard, SP ;Shutes-David, A.;Lopez, OL ;Kofler, J.;Kaye, JA ;Woltjer, R.;Nelson, PT ;Neltner, JH ;Jicha, GA ;Galasko, D.;Masliah, E.;Leverenz, JB ;Yu, CE ;Tsuang, D. "APOE DNA methylation is altered in Lewy body dementia." Alzheimer's & dementia : the journal of the Alzheimer's Association 14, 7 (2018): 889-894. [PubMed Link] | [ Full text ]
Abner, EL ;Neltner, JH ;Jicha, GA ;Patel, E.;Anderson, SL ;Wilcock, DM ;Van Eldik, LJ ;Nelson, PT "Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques." Journal of Alzheimer's disease : JAD 64, 4 (2018): 1307-1324. [PubMed Link] | [ Full text ]
Kovacs, GG ;Xie, SX ;Lee, EB ;Robinson, JL ;Caswell, C.;Irwin, DJ ;Toledo, JB ;Johnson, VE ;Smith, DH ;Alafuzoff, I.;Attems, J.;Bencze, J.;Bieniek, KF ;Bigio, EH ;Bodi, I.;Budka, H.;Dickson, DW ;Dugger, BN ;Duyckaerts, C.;Ferrer, I.;Forrest, SL ;Gelpi, E.;Gentleman, SM ;Giaccone, G.;Grinberg, LT ;Halliday, GM ;Hatanpaa, KJ ;Hof, PR ;Hofer, M.;Hortobágyi, T.;Ironside, JW ;King, A.;Kofler, J.;Kövari, E.;Kril, JJ ;Love, S.;Mackenzie, IR ;Mao, Q.;Matej, R.;McLean, C.;Munoz, DG ;Murray, ME ;Neltner, J.;Nelson, PT ;Ritchie, D.;Rodriguez, RD ;Rohan, Z.;Rozemuller, A.;Sakai, K.;Schultz, C.;Seilhean, D.;Smith, V.;Tacik, P.;Takahashi, H.;Takao, M.;Rudolf Thal, D.;Weis, S.;Wharton, SB ;White CL, 3rd ;Woulfe, JM ;Yamada, M.;Trojanowski, JQ "Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)." Journal of neuropathology and experimental neurology 76, 7 (2017): 605-619. [PubMed Link] | [ Full text ]
Ighodaro, ET ;Abner, EL ;Fardo, DW ;Lin, AL ;Katsumata, Y.;Schmitt, FA ;Kryscio, RJ ;Jicha, GA ;Neltner, JH ;Monsell, SE ;Kukull, WA ;Moser, DK ;Appiah, F.;Bachstetter, AD ;Van Eldik, LJ ;Alzheimer's Disease Neuroimaging Initiative, (ADNI). ;Nelson, PT "Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 1 (2017): 201-216. [PubMed Link] | [ Full text ]
Berger, JR ;Miller, CS ;Danaher, RJ ;Doyle, K.;Simon, KJ ;Norton, E.;Gorelik, L.;Cahir-McFarland, E.;Singhal, D.;Hack, N.;Owens, JR ;Nelson, PT ;Neltner, JH "Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA." JAMA neurology 74, 4 (2017): 437-444. [PubMed Link] | [ Full text ]
Bachstetter, AD ;Ighodaro, ET ;Hassoun, Y.;Aldeiri, D.;Neltner, JH ;Patel, E.;Abner, EL ;Nelson, PT "Rod-shaped microglia morphology is associated with aging in 2 human autopsy series." Neurobiology of aging 52, (2017): 98-105. [PubMed Link] | [ Full text ]
Nelson, PT ;Trojanowski, JQ ;Abner, EL ;Al-Janabi, OM ;Jicha, GA ;Schmitt, FA ;Smith, CD ;Fardo, DW ;Wang, WX ;Kryscio, RJ ;Neltner, JH ;Kukull, WA ;Cykowski, MD ;Van Eldik, LJ ;Ighodaro, ET ""New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)." Journal of neuropathology and experimental neurology 75, 6 (2016): 482-98. [PubMed Link] | [ Full text ]
Neltner, JH ;Abner, EL ;Jicha, GA ;Schmitt, FA ;Patel, E.;Poon, LW ;Marla, G.;Green, RC ;Davey, A.;Johnson, MA ;Jazwinski, SM ;Kim, S.;Davis, D.;Woodard, JL ;Kryscio, RJ ;Van Eldik, LJ ;Nelson, PT "Brain pathologies in extreme old age." Neurobiology of aging 37, (2016): 1-11. [PubMed Link] | [ Full text ]
Yu, T.;Chen, X.;Zhang, W.;Liu, J.;Avdiushko, R.;Napier, DL ;Liu, AX ;Neltner, JM ;Wang, C.;Cohen, D.;Liu, C. "KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer." Cell death and differentiation 23, 2 (2016): 207-15. [PubMed Link] | [ Full text ]
Bachstetter, AD ;Van Eldik, LJ ;Schmitt, FA ;Neltner, JH ;Ighodaro, ET ;Webster, SJ ;Patel, E.;Abner, EL ;Kryscio, RJ ;Nelson, PT "Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging." Acta neuropathologica communications 3, (2015): 32. [PubMed Link] | [ Full text ]
Hance, JM ;Harris, JW ;Neltner, J.;Vilchez, V.;Tzeng, CW ;Maynard, E.;Gedaly, R.;Shah, MB "Hepatobiliary mucinous cystadenoma resulting in biliary obstruction." The American surgeon 81, 6 (2015): E238-9. [PubMed Link] | [ Full text ]
Hensley, P.;Hilal, T.;Neltner, J.;Kumar, B. "Maintaining sharp focus on a grainy film: miliary pattern in an elderly woman with acute respiratory failure." BMJ case reports 2015, (2015): [PubMed Link] | [ Full text ]
Ighodaro, ET ;Jicha, GA ;Schmitt, FA ;Neltner, JH ;Abner, EL ;Kryscio, RJ ;Smith, CD ;Duplessis, T.;Anderson, S.;Patel, E.;Bachstetter, A.;Van Eldik, LJ ;Nelson, PT "Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature." Journal of neuropathology and experimental neurology 74, 7 (2015): 642-52. [PubMed Link] | [ Full text ]
Fiore, LS ;Ganguly, SS ;Sledziona, J.;Cibull, ML ;Wang, C.;Richards, DL ;Neltner, JM ;Beach, C.;McCorkle, JR ;Kaetzel, DM ;Plattner, R. "c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer." Oncogene 33, 36 (2014): 4508-4520. [PubMed Link] | [ Full text ]
Berger, JR ;Neltner, J.;Smith, C.;Cambi, F. "Posterior reversible encephalopathy syndrome masquerading as progressive multifocal leukoencephalopathy in rituximab treated neuromyelitis optica." Multiple sclerosis and related disorders 3, 6 (2014): 728-31. [PubMed Link] | [ Full text ]
Zaytseva, YY ;Elliott, VA ;Rychahou, P.;Mustain, WC ;Kim, JT ;Valentino, J.;Gao, T.;O'Connor, KL ;Neltner, JM ;Lee, EY ;Weiss, HL ;Evers, BM "Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer." Carcinogenesis 35, 6 (2014): 1341-51. [PubMed Link] | [ Full text ]
Neltner, JH ;Abner, EL ;Baker, S.;Schmitt, FA ;Kryscio, RJ ;Jicha, GA ;Smith, CD ;Hammack, E.;Kukull, WA ;Brenowitz, WD ;Van Eldik, LJ ;Nelson, PT "Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing." Brain : a journal of neurology 137, Pt 1 (2014): 255-67. [PubMed Link] | [ Full text ]
Gilbert, MR ;Liu, Y.;Neltner, J.;Pu, H.;Morris, A.;Sunkara, M.;Pittman, T.;Kyprianou, N.;Horbinski, C. "Autophagy and oxidative stress in gliomas with IDH1 mutations." Acta neuropathologica 127, 2 (2014): 221-33. [PubMed Link] | [ Full text ]
Wang, WX ;Danaher, RJ ;Miller, CS ;Berger, JR ;Nubia, VG ;Wilfred, BS ;Neltner, JH ;Norris, CM ;Nelson, PT "Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells." Genomics, proteomics & bioinformatics 12, 1 (2014): 19-30. [PubMed Link] | [ Full text ]
Crary, JF ;Trojanowski, JQ ;Schneider, JA ;Abisambra, JF ;Abner, EL ;Alafuzoff, I.;Arnold, SE ;Attems, J.;Beach, TG ;Bigio, EH ;Cairns, NJ ;Dickson, DW ;Gearing, M.;Grinberg, LT ;Hof, PR ;Hyman, BT ;Jellinger, K.;Jicha, GA ;Kovacs, GG ;Knopman, DS ;Kofler, J.;Kukull, WA ;Mackenzie, IR ;Masliah, E.;McKee, A.;Montine, TJ ;Murray, ME ;Neltner, JH ;Santa-Maria, I.;Seeley, WW ;Serrano-Pozo, A.;Shelanski, ML ;Stein, T.;Takao, M.;Thal, DR ;Toledo, JB ;Troncoso, JC ;Vonsattel, JP ;White CL, 3rd ;Wisniewski, T.;Woltjer, RL ;Yamada, M.;Nelson, PT "Primary age-related tauopathy (PART): a common pathology associated with human aging." Acta neuropathologica 128, 6 (2014): 755-66. [PubMed Link] | [ Full text ]
Scheff, SW ;Neltner, JH ;Nelson, PT "Is synaptic loss a unique hallmark of Alzheimer's disease?" Biochemical pharmacology 88, 4 (2014): 517-28. [PubMed Link] | [ Full text ]
Nelson, PT ;Estus, S.;Abner, EL ;Parikh, I.;Malik, M.;Neltner, JH ;Ighodaro, E.;Wang, WX ;Wilfred, BR ;Wang, LS ;Kukull, WA ;Nandakumar, K.;Farman, ML ;Poon, WW ;Corrada, MM ;Kawas, CH ;Cribbs, DH ;Bennett, DA ;Schneider, JA ;Larson, EB ;Crane, PK ;Valladares, O.;Schmitt, FA ;Kryscio, RJ ;Jicha, GA ;Smith, CD ;Scheff, SW ;Sonnen, JA ;Haines, JL ;Pericak-Vance, MA ;Mayeux, R.;Farrer, LA ;Van Eldik, LJ ;Horbinski, C.;Green, RC ;Gearing, M.;Poon, LW ;Kramer, PL ;Woltjer, RL ;Montine, TJ ;Partch, AB ;Rajic, AJ ;Richmire, K.;Monsell, SE ;Alzheimer’ Disease Genetic, Consortium. ;Schellenberg, GD ;Fardo, DW "ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology." Acta neuropathologica 127, 6 (2014): 825-43. [PubMed Link] | [ Full text ]
Attems, J.;Neltner, JH ;Nelson, PT "Quantitative neuropathological assessment to investigate cerebral multi-morbidity." Alzheimer's research & therapy 6, 9 (2014): 85. [PubMed Link] | [ Full text ]
Tsuang, D.;Leverenz, JB ;Lopez, OL ;Hamilton, RL ;Bennett, DA ;Schneider, JA ;Buchman, AS ;Larson, EB ;Crane, PK ;Kaye, JA ;Kramer, P.;Woltjer, R.;Trojanowski, JQ ;Weintraub, D.;Chen-Plotkin, AS ;Irwin, DJ ;Rick, J.;Schellenberg, GD ;Watson, GS ;Kukull, W.;Nelson, PT ;Jicha, GA ;Neltner, JH ;Galasko, D.;Masliah, E.;Quinn, JF ;Chung, KA ;Yearout, D.;Mata, IF ;Wan, JY ;Edwards, KL ;Montine, TJ ;Zabetian, CP "APOE ε4 increases risk for dementia in pure synucleinopathies." JAMA neurology 70, 2 (2013): 223-8. [PubMed Link] | [ Full text ]
Nelson, PT ;Smith, CD ;Abner, EL ;Wilfred, BJ ;Wang, WX ;Neltner, JH ;Baker, M.;Fardo, DW ;Kryscio, RJ ;Scheff, SW ;Jicha, GA ;Jellinger, KA ;Van Eldik, LJ ;Schmitt, FA "Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease." Acta neuropathologica 126, 2 (2013): 161-77. [PubMed Link] | [ Full text ]
Tsuang, D.;Leverenz, JB ;Lopez, OL ;Hamilton, RL ;Bennett, DA ;Schneider, JA ;Buchman, AS ;Larson, EB ;Crane, PK ;Kaye, JA ;Kramer, P.;Woltjer, R.;Kukull, W.;Nelson, PT ;Jicha, GA ;Neltner, JH ;Galasko, D.;Masliah, E.;Trojanowski, JQ ;Schellenberg, GD ;Yearout, D.;Huston, H.;Fritts-Penniman, A.;Mata, IF ;Wan, JY ;Edwards, KL ;Montine, TJ ;Zabetian, CP "GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology." Neurology 79, 19 (2012): 1944-50. [PubMed Link] | [ Full text ]
Bachstetter, AD ;Norris, CM ;Sompol, P.;Wilcock, DM ;Goulding, D.;Neltner, JH ;St Clair, D.;Watterson, DM ;Van Eldik, LJ "Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 30 (2012): 10201-10. [PubMed Link] | [ Full text ]
Neltner, JH ;Abner, EL ;Schmitt, FA ;Denison, SK ;Anderson, S.;Patel, E.;Nelson, PT "Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes." Journal of neuropathology and experimental neurology 71, 12 (2012): 1075-85. [PubMed Link] | [ Full text ]
Nelson, PT ;Schmitt, FA ;Lin, Y.;Abner, EL ;Jicha, GA ;Patel, E.;Thomason, PC ;Neltner, JH ;Smith, CD ;Santacruz, KS ;Sonnen, JA ;Poon, LW ;Gearing, M.;Green, RC ;Woodard, JL ;Van Eldik, LJ ;Kryscio, RJ "Hippocampal sclerosis in advanced age: clinical and pathological features." Brain : a journal of neurology 134, Pt 5 (2011): 1506-18. [PubMed Link] | [ Full text ]
Nelson, PT ;Head, E.;Schmitt, FA ;Davis, PR ;Neltner, JH ;Jicha, GA ;Abner, EL ;Smith, CD ;Van Eldik, LJ ;Kryscio, RJ ;Scheff, SW "Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies." Acta neuropathologica 121, 5 (2011): 571-87. [PubMed Link] | [ Full text ]
Abner, EL ;Kryscio, RJ ;Schmitt, FA ;Santacruz, KS ;Jicha, GA ;Lin, Y.;Neltner, JM ;Smith, CD ;Van Eldik, LJ ;Nelson, PT ""End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?" Journal of Alzheimer's disease : JAD 25, 3 (2011): 445-53. [PubMed Link] | [ Full text ]