Janna Neltner, MD | Pathology & Laboratory Medicine

Janna Neltner, MD

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jmhack0@email.uky.edu
MS 155

Position(s):

Assistant Professor

Director - Pathology Residency Program

Affiliation(s):

Pathology & Laboratory Medicine

Interests / Specialties:

Anatomical and Clinical Pathology and Neuropathology

Bio / Education:

University of Kentucky - Doctor of Medicine
University of Kentucky - Residency (AP/CP)
University of Kentucky - Fellowship (Neuropathology)

Research Description:

- Pathologic examination of neurodegenerative diseases, including Alzheimer's disease, synucleinopathies, and hippocampal sclerosis (of aging).
- The use of digital image analysis for quantification of findings in neurodegenerative and tumor processes.

PubMed Publications:

Tulloch, J.; Leong, L.; Chen, S.; Keene, CD ; Millard, SP ; Shutes-David, A.; Lopez, OL ; Kofler, J.; Kaye, JA ; Woltjer, R.; Nelson, PT ; Neltner, JH ; Jicha, GA ; Galasko, D.; Masliah, E.; Leverenz, JB ; Yu, CE ; Tsuang, D. "APOE DNA methylation is altered in Lewy body dementia." Alzheimer's & dementia : the journal of the Alzheimer's Association 14, 7 (2018): 889-894. [PubMed Link] | [ Full text ]
Abner, EL ; Neltner, JH ; Jicha, GA ; Patel, E.; Anderson, SL ; Wilcock, DM ; Van Eldik, LJ ; Nelson, PT "Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques." Journal of Alzheimer's disease : JAD 64, 4 (2018): 1307-1324. [PubMed Link] | [ Full text ]
Kovacs, GG ; Xie, SX ; Lee, EB ; Robinson, JL ; Caswell, C.; Irwin, DJ ; Toledo, JB ; Johnson, VE ; Smith, DH ; Alafuzoff, I.; Attems, J.; Bencze, J.; Bieniek, KF ; Bigio, EH ; Bodi, I.; Budka, H.; Dickson, DW ; Dugger, BN ; Duyckaerts, C.; Ferrer, I.; Forrest, SL ; Gelpi, E.; Gentleman, SM ; Giaccone, G.; Grinberg, LT ; Halliday, GM ; Hatanpaa, KJ ; Hof, PR ; Hofer, M.; Hortobágyi, T.; Ironside, JW ; King, A.; Kofler, J.; Kövari, E.; Kril, JJ ; Love, S.; Mackenzie, IR ; Mao, Q.; Matej, R.; McLean, C.; Munoz, DG ; Murray, ME ; Neltner, J.; Nelson, PT ; Ritchie, D.; Rodriguez, RD ; Rohan, Z.; Rozemuller, A.; Sakai, K.; Schultz, C.; Seilhean, D.; Smith, V.; Tacik, P.; Takahashi, H.; Takao, M.; Rudolf Thal, D.; Weis, S.; Wharton, SB ; White CL, 3rd ; Woulfe, JM ; Yamada, M.; Trojanowski, JQ "Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)." Journal of neuropathology and experimental neurology 76, 7 (2017): 605-619. [PubMed Link] | [ Full text ]
Ighodaro, ET ; Abner, EL ; Fardo, DW ; Lin, AL ; Katsumata, Y.; Schmitt, FA ; Kryscio, RJ ; Jicha, GA ; Neltner, JH ; Monsell, SE ; Kukull, WA ; Moser, DK ; Appiah, F.; Bachstetter, AD ; Van Eldik, LJ ; Alzheimer's Disease Neuroimaging Initiative, (ADNI). ; Nelson, PT "Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 1 (2017): 201-216. [PubMed Link] | [ Full text ]
Berger, JR ; Miller, CS ; Danaher, RJ ; Doyle, K.; Simon, KJ ; Norton, E.; Gorelik, L.; Cahir-McFarland, E.; Singhal, D.; Hack, N.; Owens, JR ; Nelson, PT ; Neltner, JH "Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA." JAMA neurology 74, 4 (2017): 437-444. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Ighodaro, ET ; Hassoun, Y.; Aldeiri, D.; Neltner, JH ; Patel, E.; Abner, EL ; Nelson, PT "Rod-shaped microglia morphology is associated with aging in 2 human autopsy series." Neurobiology of aging 52, (2017): 98-105. [PubMed Link] | [ Full text ]
Nelson, PT ; Trojanowski, JQ ; Abner, EL ; Al-Janabi, OM ; Jicha, GA ; Schmitt, FA ; Smith, CD ; Fardo, DW ; Wang, WX ; Kryscio, RJ ; Neltner, JH ; Kukull, WA ; Cykowski, MD ; Van Eldik, LJ ; Ighodaro, ET ""New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)." Journal of neuropathology and experimental neurology 75, 6 (2016): 482-98. [PubMed Link] | [ Full text ]
Neltner, JH ; Abner, EL ; Jicha, GA ; Schmitt, FA ; Patel, E.; Poon, LW ; Marla, G.; Green, RC ; Davey, A.; Johnson, MA ; Jazwinski, SM ; Kim, S.; Davis, D.; Woodard, JL ; Kryscio, RJ ; Van Eldik, LJ ; Nelson, PT "Brain pathologies in extreme old age." Neurobiology of aging 37, (2016): 1-11. [PubMed Link] | [ Full text ]
Yu, T.; Chen, X.; Zhang, W.; Liu, J.; Avdiushko, R.; Napier, DL ; Liu, AX ; Neltner, JM ; Wang, C.; Cohen, D.; Liu, C. "KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer." Cell death and differentiation 23, 2 (2016): 207-15. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Van Eldik, LJ ; Schmitt, FA ; Neltner, JH ; Ighodaro, ET ; Webster, SJ ; Patel, E.; Abner, EL ; Kryscio, RJ ; Nelson, PT "Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging." Acta neuropathologica communications 3, (2015): 32. [PubMed Link] | [ Full text ]
Hance, JM ; Harris, JW ; Neltner, J.; Vilchez, V.; Tzeng, CW ; Maynard, E.; Gedaly, R.; Shah, MB "Hepatobiliary mucinous cystadenoma resulting in biliary obstruction." The American surgeon 81, 6 (2015): E238-9. [PubMed Link] | [ Full text ]
Hensley, P.; Hilal, T.; Neltner, J.; Kumar, B. "Maintaining sharp focus on a grainy film: miliary pattern in an elderly woman with acute respiratory failure." BMJ case reports 2015, (2015): [PubMed Link] | [ Full text ]
Ighodaro, ET ; Jicha, GA ; Schmitt, FA ; Neltner, JH ; Abner, EL ; Kryscio, RJ ; Smith, CD ; Duplessis, T.; Anderson, S.; Patel, E.; Bachstetter, A.; Van Eldik, LJ ; Nelson, PT "Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature." Journal of neuropathology and experimental neurology 74, 7 (2015): 642-52. [PubMed Link] | [ Full text ]
Fiore, LS ; Ganguly, SS ; Sledziona, J.; Cibull, ML ; Wang, C.; Richards, DL ; Neltner, JM ; Beach, C.; McCorkle, JR ; Kaetzel, DM ; Plattner, R. "c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer." Oncogene 33, 36 (2014): 4508-4520. [PubMed Link] | [ Full text ]
Berger, JR ; Neltner, J.; Smith, C.; Cambi, F. "Posterior reversible encephalopathy syndrome masquerading as progressive multifocal leukoencephalopathy in rituximab treated neuromyelitis optica." Multiple sclerosis and related disorders 3, 6 (2014): 728-31. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Elliott, VA ; Rychahou, P.; Mustain, WC ; Kim, JT ; Valentino, J.; Gao, T.; O'Connor, KL ; Neltner, JM ; Lee, EY ; Weiss, HL ; Evers, BM "Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer." Carcinogenesis 35, 6 (2014): 1341-51. [PubMed Link] | [ Full text ]
Neltner, JH ; Abner, EL ; Baker, S.; Schmitt, FA ; Kryscio, RJ ; Jicha, GA ; Smith, CD ; Hammack, E.; Kukull, WA ; Brenowitz, WD ; Van Eldik, LJ ; Nelson, PT "Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing." Brain : a journal of neurology 137, Pt 1 (2014): 255-67. [PubMed Link] | [ Full text ]
Gilbert, MR ; Liu, Y.; Neltner, J.; Pu, H.; Morris, A.; Sunkara, M.; Pittman, T.; Kyprianou, N.; Horbinski, C. "Autophagy and oxidative stress in gliomas with IDH1 mutations." Acta neuropathologica 127, 2 (2014): 221-33. [PubMed Link] | [ Full text ]
Wang, WX ; Danaher, RJ ; Miller, CS ; Berger, JR ; Nubia, VG ; Wilfred, BS ; Neltner, JH ; Norris, CM ; Nelson, PT "Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells." Genomics, proteomics & bioinformatics 12, 1 (2014): 19-30. [PubMed Link] | [ Full text ]
Crary, JF ; Trojanowski, JQ ; Schneider, JA ; Abisambra, JF ; Abner, EL ; Alafuzoff, I.; Arnold, SE ; Attems, J.; Beach, TG ; Bigio, EH ; Cairns, NJ ; Dickson, DW ; Gearing, M.; Grinberg, LT ; Hof, PR ; Hyman, BT ; Jellinger, K.; Jicha, GA ; Kovacs, GG ; Knopman, DS ; Kofler, J.; Kukull, WA ; Mackenzie, IR ; Masliah, E.; McKee, A.; Montine, TJ ; Murray, ME ; Neltner, JH ; Santa-Maria, I.; Seeley, WW ; Serrano-Pozo, A.; Shelanski, ML ; Stein, T.; Takao, M.; Thal, DR ; Toledo, JB ; Troncoso, JC ; Vonsattel, JP ; White CL, 3rd ; Wisniewski, T.; Woltjer, RL ; Yamada, M.; Nelson, PT "Primary age-related tauopathy (PART): a common pathology associated with human aging." Acta neuropathologica 128, 6 (2014): 755-66. [PubMed Link] | [ Full text ]
Scheff, SW ; Neltner, JH ; Nelson, PT "Is synaptic loss a unique hallmark of Alzheimer's disease?" Biochemical pharmacology 88, 4 (2014): 517-28. [PubMed Link] | [ Full text ]
Nelson, PT ; Estus, S.; Abner, EL ; Parikh, I.; Malik, M.; Neltner, JH ; Ighodaro, E.; Wang, WX ; Wilfred, BR ; Wang, LS ; Kukull, WA ; Nandakumar, K.; Farman, ML ; Poon, WW ; Corrada, MM ; Kawas, CH ; Cribbs, DH ; Bennett, DA ; Schneider, JA ; Larson, EB ; Crane, PK ; Valladares, O.; Schmitt, FA ; Kryscio, RJ ; Jicha, GA ; Smith, CD ; Scheff, SW ; Sonnen, JA ; Haines, JL ; Pericak-Vance, MA ; Mayeux, R.; Farrer, LA ; Van Eldik, LJ ; Horbinski, C.; Green, RC ; Gearing, M.; Poon, LW ; Kramer, PL ; Woltjer, RL ; Montine, TJ ; Partch, AB ; Rajic, AJ ; Richmire, K.; Monsell, SE ; Alzheimer’ Disease Genetic, Consortium. ; Schellenberg, GD ; Fardo, DW "ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology." Acta neuropathologica 127, 6 (2014): 825-43. [PubMed Link] | [ Full text ]
Attems, J.; Neltner, JH ; Nelson, PT "Quantitative neuropathological assessment to investigate cerebral multi-morbidity." Alzheimer's research & therapy 6, 9 (2014): 85. [PubMed Link] | [ Full text ]
Tsuang, D.; Leverenz, JB ; Lopez, OL ; Hamilton, RL ; Bennett, DA ; Schneider, JA ; Buchman, AS ; Larson, EB ; Crane, PK ; Kaye, JA ; Kramer, P.; Woltjer, R.; Trojanowski, JQ ; Weintraub, D.; Chen-Plotkin, AS ; Irwin, DJ ; Rick, J.; Schellenberg, GD ; Watson, GS ; Kukull, W.; Nelson, PT ; Jicha, GA ; Neltner, JH ; Galasko, D.; Masliah, E.; Quinn, JF ; Chung, KA ; Yearout, D.; Mata, IF ; Wan, JY ; Edwards, KL ; Montine, TJ ; Zabetian, CP "APOE ε4 increases risk for dementia in pure synucleinopathies." JAMA neurology 70, 2 (2013): 223-8. [PubMed Link] | [ Full text ]
Nelson, PT ; Smith, CD ; Abner, EL ; Wilfred, BJ ; Wang, WX ; Neltner, JH ; Baker, M.; Fardo, DW ; Kryscio, RJ ; Scheff, SW ; Jicha, GA ; Jellinger, KA ; Van Eldik, LJ ; Schmitt, FA "Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease." Acta neuropathologica 126, 2 (2013): 161-77. [PubMed Link] | [ Full text ]
Tsuang, D.; Leverenz, JB ; Lopez, OL ; Hamilton, RL ; Bennett, DA ; Schneider, JA ; Buchman, AS ; Larson, EB ; Crane, PK ; Kaye, JA ; Kramer, P.; Woltjer, R.; Kukull, W.; Nelson, PT ; Jicha, GA ; Neltner, JH ; Galasko, D.; Masliah, E.; Trojanowski, JQ ; Schellenberg, GD ; Yearout, D.; Huston, H.; Fritts-Penniman, A.; Mata, IF ; Wan, JY ; Edwards, KL ; Montine, TJ ; Zabetian, CP "GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology." Neurology 79, 19 (2012): 1944-50. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Norris, CM ; Sompol, P.; Wilcock, DM ; Goulding, D.; Neltner, JH ; St Clair, D.; Watterson, DM ; Van Eldik, LJ "Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 30 (2012): 10201-10. [PubMed Link] | [ Full text ]
Neltner, JH ; Abner, EL ; Schmitt, FA ; Denison, SK ; Anderson, S.; Patel, E.; Nelson, PT "Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes." Journal of neuropathology and experimental neurology 71, 12 (2012): 1075-85. [PubMed Link] | [ Full text ]
Nelson, PT ; Schmitt, FA ; Lin, Y.; Abner, EL ; Jicha, GA ; Patel, E.; Thomason, PC ; Neltner, JH ; Smith, CD ; Santacruz, KS ; Sonnen, JA ; Poon, LW ; Gearing, M.; Green, RC ; Woodard, JL ; Van Eldik, LJ ; Kryscio, RJ "Hippocampal sclerosis in advanced age: clinical and pathological features." Brain : a journal of neurology 134, Pt 5 (2011): 1506-18. [PubMed Link] | [ Full text ]
Nelson, PT ; Head, E.; Schmitt, FA ; Davis, PR ; Neltner, JH ; Jicha, GA ; Abner, EL ; Smith, CD ; Van Eldik, LJ ; Kryscio, RJ ; Scheff, SW "Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies." Acta neuropathologica 121, 5 (2011): 571-87. [PubMed Link] | [ Full text ]
Abner, EL ; Kryscio, RJ ; Schmitt, FA ; Santacruz, KS ; Jicha, GA ; Lin, Y.; Neltner, JM ; Smith, CD ; Van Eldik, LJ ; Nelson, PT ""End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?" Journal of Alzheimer's disease : JAD 25, 3 (2011): 445-53. [PubMed Link] | [ Full text ]