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Melissa Kesler, MD

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melissa.kesler@uky.edu
MS 143

Positions

  • Associate Professor
  • Director - Hematopathology

College Unit(s)

Biography and Education

Education

B.S. in Biology - University of Kentucky (1993)
MD - University of Kentucky (1999)
AP/CP Residency - University of Kentucky (2003)
Hematopathology Fellowship - University of Texas Southwestern (2005)

Selected Publications

Publications & Other Scholarly Work:

1     Shaw BC, Maglinger GB, Ujas T, Rupareliya C, Fraser JF, Grupke S, Kesler M, Gelderblom M, Pennypacker KR, Turchan-Cholewo J, Stowe AM. Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy. J Cereb Blood Flow Metab. 2021 Jul 11:271678X211028496. doi: 10.1177/0271678X211028496. Epub ahead of print. PMID: 34250820.

2     Palaniyandi S, Kumari R, Venniyil Radhakrishnan S, Strattan E, Hakim N, Munker R, Kesler MV, Hildebrandt GC. The Prolyl Hydroxylase Inhibitor Dimethyl Oxalyl Glycine Decreases Early Gastrointestinal GVHD in Experimental Allogeneic Hematopoietic Cell Transplantation. Transplantation. 2020 Dec;104(12):2507-2515. doi: 10.1097/TP.0000000000003383. PMID: 32639407; PMCID: PMC8139022.

3     Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R. Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database. Leuk Res. 2020 Feb;89:106301. doi: 10.1016/j.leukres.2020.106301. Epub 2020 Jan 17. PMID: 31982153.

4     Palaniyandi S, Kumari R, Strattan E, Huang T, Du J, Hakim N, Kesler MV, Hildebrandt GC. The α4β7 blockade with vedolizumab is effective in prevention of graft vs. host disease using a xenogeneic mouse model. Am J Hematol. 2020 Feb;95(2):E39-E41. doi: 10.1002/ajh.25678. Epub 2019 Dec 11. PMID: 31724186.

5     Strattan E, Palaniyandi S, Kumari R, Du J, Hakim N, Huang T, Kesler MV, Jennings CD, Sturgill JL, Hildebrandt GC. Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease. Front Immunol. 2019 Oct 18;10:2470. doi: 10.3389/fimmu.2019.02470. PMID: 31681336; PMCID: PMC6813249.

6     Kumari R, Palaniyandi S, Strattan E, Huang T, Kohler K, Jabbour N, Dalland J, Du J, Kesler MV, Chen YH, Hildebrandt GC. TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation. Transplantation. 2020 Mar;104(3):500-510. doi: 10.1097/TP.0000000000003013. PMID: 31634333; PMCID: PMC8183110.

7     H Jang, E,Oakley, M,Forbes-Osborne, M,Kesler, R Norcross, A Morris E,Galperin. Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome. Human Molecular Genetics, ddy366,

8     R Kumari, S Palaniyandi, E Strattan, K Kohler, N Jabbour,  J Dalland, M Kesler, and GC Hildebrandt.  “3169 TNFAIP8 (TIPE) Deficiency Exacerbates Acute Graft Versus-Host Disease in Murine Model.” American Society of Hematology Meeting 2017 December 9-12; Atlanta, GA.

9     Saeed H, Herzig R, Kesler MV. “T-Lymphoblastic Leukemia” in Gulati GL, Filicko-O’Hara J, Krause J (Eds). Case Studies in Hematology and Coagulation 2nd edition. ASCO May 2019.

10   Senthilnathan Palaniyandi, Ph.D, Reena Kumari, Ph.D, Joanna Dalland, MD, Melissa Kesler, MD and Gerhard C Hildebrandt, MD. “Protective Effect of Curcumin in Murine Graft Versus Host Disease after Allogeneic Hematopoietic Cell Transplantation.” American Society of Blood and Marrow Transplantation Annual Meeting 2017 February 22-26; Orlando, FL.

11   Shah K, Kesler MV. A Case of Epstein Barr Virus-Related Hemophagocytic Lymphohistiocytosis in Association with Pembrolizumab Therapy. [abstract]. American Society of Clinical Pathologists Annual Meeting; 2017 September 6-8; Chicago, IL.

12   Dalland JC, Piecoro DW, Kesler MV, Wagner LM, Arora R. “Relapsed Blastic Plasmacytoid  Dendritic Cell Neoplasm Versus Fungal Infection: Pitfalls in Pathology” [abstract]. Accepted in: American Society of Clinical Pathologists Annual Meeting; 2017 September 6-8; Chicago, IL.

13   Kumari R, Palaniyandi S, Radhakrishnan SV, Karlsson F, Kesler M, Hildebrandt GC. The prolyl hydroxylase inhibitor dimethyl oxalyl glycine decreases early gastrointestinal GVHD and is associated with less severe non-infectious lung injury after allogeneic hemoatopoietic stem cell transplantation. Poster/abstract presentation at Markey Cancer Research Symposium 2016.

14   Palaniyandi S, Kumari R, Radhakrishnan SV, Kesler M, Hildebrandt GC. Protective effect of curcumin an murine GVHD after allogeneic stem cell Transplant Poster/abstract presentation at Markey Cancer Research Symposium 2016

15   Khan MW, Hadley T, Kesler M, Gul Z. IgG4-related disease: a rare disease with an unusual presentation. Clin Case Rep 2016 Jun1;4(7): 657-60.

16   Kesler MV. Hemophagocytic Lymphohistiocytosis.  Discussion for CheckPath Hematopathology  2015

17   Kesler MV. Cystinosis. Discussion for CheckPath Hematopathology  2015.

18   Kesler MV. Myeloid sarcoma. Discussion for CheckPath Hematopathology  2013.

19   Kesler, MV. Hairy cell leukemia. Discussion for CheckPath Hematopathology 2014

20   Ye Z, Eickhoff J, Kesler MV. Eosinophilic Pseudoleukemia Due to Toxocariasis in a 3-year-old Patient: Report of A Rare Case. Poster presentation at ASCP 2014 Annual Meeting, Tampa, FL October 6-8, 2014.

21   Ye Z , Kesler M, Bensema M. Sclerosing Angiomatoid Nodular Transformation Of the Spleen. Arch Pathol Lab Med 2013; 137:1349A.

22   Kesler, M. and Fleischman, R.A. A Familial Cluster of Myelodysplasia and Myelofibrosis. 7th Biennial International Congress on Myeloproliferative Neoplasms & Myelo­dys­plasia, Brooklyn, NY, November 7-8, 2013.

23   Matnani RG, Stewart RL, Pulliam JP, Jennings CD, Kesler MV. Peripheral T Cell Lymphoma with Aberrant Expression of CD19, CD20 and CD79a: Case Report And Review of the Literature. Case Rep Hematol 2013.

24   Kesler MV. Babesiosis. Discussion for CheckPath Hematopathology 2013.

25   Kesler, MV. Acute megakaryoblastic leukemia. Discussion for CheckPath Hematopathology  2013.

26   Kesler MV. Disseminated Histoplasmosis. Discussion for CheckPath Hematopathology 2012.

27   Kesler MV. Accelerated phase chronic myeloid leukemia. Discussion for CheckPath Hematopathology 2012.

28   Scott TL, Christian PA, Kesler MV, Donohue KM, Shelton B, Wakamatsu K, Ito S, D'Orazio J. Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation. Exp Dermatol. 2012 Oct;21(10):771-7.

29   Kesler MV. Cold agglutinin disease. Discussion for CheckPath Hematopathology

30   Diaz-Guzman E, Dong B, Hobbs SB, Kesler MV, Hays Jr. D. Hemophagocytic

31   Hays Jr. D, Kesler MV, Skinner SC, Attili AK. Nineteen year old female with progressive dyspnea and multiple pulmonary nodules. Chest 2011 Jul; 140(1): 253-7.

32   Korrect GS, Kesler MV, Strup SE. Aggressive angiomyxoma presenting as urinary retention in a male: a case report and literature review. The Canadian Journal of Urology 2011 Oct; 18(5): 5343-5345.

33   Kesler MV. Rosai-Dorfman disease. Discussion for CheckPath Hematopathology 2011

34   Kesler MV.  Splenic marginal zone lymphoma. Discussion for CheckPath Hematopathology 2010.

35   Kesler MV. Amyloidosis. Discussion for CheckPath Hematopathology 2010.

36   Kesler MV.  Spur Cell Anemia. Discussion for CheckPath Hematopathology 2009

37   Kesler MV. Castleman’s Disease. Discussion for CheckPath Hematopathology 2009

38   D’Orazio JA, Burns LA, Farhoudi N, McBride MT, Kesler MV. Acute Myeloid Leukemia Presenting as Acute Infectious Meningitis in a 7 Year Old Boy.  Clinical Pediatrics 2009 May; 48(4): 444-8.

39   Kesler MV. Nodular Sclerosis Hodgkin Lymphoma. Discussion for CheckPath Hematopathology 2008.

40   Kesler MV. Pelger-Huet Anomaly. Discussion for CheckPath Hematopathology 2008

41   Kesler MV, Paranjape GS, Asplund SL, et al. Anaplastic large cell lymphoma: a Flow cytometric analysis of 29 cases. American Journal of Clinical Pathology  2007 Aug;128(2):314-22. 

42   Kesler MV. Anaplastic Large Cell Lymphoma. Discussion for CheckPath Hematopathology 2007.

43   Kesler MV. Mantle Cell Lymphoma. Discussion for CheckPath Hematopathology 2007.

44   Chen W, Kesler MV, Karandikar NJ, et al. Flow cytometric features of angioimmunoblastic T cell lymphoma. Clinical Cytometry 2006; 70B(3): 142-148.

45   Kesler MV, Xu Y, Karandikar NJ, et al. Flow cytometric comparison of  Burkittt And CD10(+) large B cell lymphoma. Modern Pathology 2005; 18(1): 237A. (Platform presentation at 2005 USCAP meeting).

46   Kesler MV, McKenna RW, Kroft SH, et al. Dual Labelling Immunohistochemistry for CD10, bcl-6, and MUM-1 in Diffuse Large B-cell Lymphoma. Modern Pathology 2004; 17(1): 254-255A.

47   Kesler MV, Willingham S, Pulliam J. MGMT Promoter Hypermethylation in Classic Hodgkin Lymphoma. Modern Pathology 2003; 16(1): 239A.

48   Kesler MV, Jennings CD, Cibull ML. Utility of Flow Cytometric Gating Patterns in B-cell Lymphoma. Modern Pathology 2002; 15(1): 246-247A.

49   Kesler MV, Absher KJ, Jennings CD, et al. CD23 Expression in MALT Lymphoma. Modern Pathology 2001; 14(1): 168A.

50   Kesler MV, Gewirtz AS. Increased Blasts in a Neonate with Trisomy 21. Laboratory Medicine 2001; 9(32):509-511.