Representative Publications & Other Scholarly Work:

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.  Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.  Brain. 2019 Apr 30. pii: awz099. doi: 10.1093/brain/awz099.

Abner EL, Nelson PT, Jicha GA, Cooper GE, Fardo DW, Schmitt FA, Kryscio RJ.  Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis.  J Alzheimers Dis. 2019;68(2):625-633. doi: 10.3233/JAD-181119.

Chornenkyy Y, Fardo DW, Nelson PT.  Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.  Lab Invest. 2019 Feb 11. doi: 10.1038/s41374-019-0196-y. [Epub ahead of print] Review.

Jicha GA, Nelson PT.  Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.  Continuum (Minneap Minn). 2019 Feb;25(1):208-233. doi: 10.1212/CON.0000000000000697.

Nelson PT, Gal Z, Wang WX, Niedowicz DM, Artiushin SC, Wycoff S, Wei A, Jicha GA, Fardo DW.  TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.  Neurobiol Dis. 2019 May;125:67-76. doi: 10.1016/j.nbd.2019.01.013. Epub 2019 Jan 23.

Katsumata Y, Fardo DW, Kukull WA, Nelson PT.  Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.  Acta Neuropathol Commun. 2018 Dec 19;6(1):142. doi: 10.1186/s40478-018-0641-y.

Niedowicz DM, Özcan S, Nelson PT.  Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice.   J Diabetes Res. 2018 Oct 29;2018:1251345. doi: 10.1155/2018/1251345. eCollection 2018.

Katsumata Y, Nelson PT, Estus S; Alzheimer's Disease Neuroimaging Initiative (ADNI), Fardo DW. Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.   Neurobiol Aging. 2019 Feb;74:135-146. doi: 10.1016/j.neurobiolaging.2018.10.017. Epub 2018 Oct 23.

Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA.  Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.  J Alzheimers Dis. 2018;66(3):1095-1104. doi: 10.3233/JAD-180663.

Trieu T, Sajjadi SA, Kawas CH, Nelson PT, Corrada MM.  Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.   Neurology. 2018 Nov 6;91(19):e1788-e1798. doi: 10.1212/WNL.0000000000006455. Epub 2018 Oct 12.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.  Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.  Nat Neurosci. 2018 Oct;21(10):1482-1492. doi: 10.1038/s41593-018-0223-0. Epub 2018 Sep 17.  PMID: 30224808

Chornenkyy Y, Wang WX, Wei A, Nelson PT*.  Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline.  Brain Pathol. 2018 Aug 14. doi: 10.1111/bpa.12655. Review.  PMID: 30106209

Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM, Van Eldik LJ, Nelson PT*.  Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques.  J Alzheimers Dis. 2018;64(4):1307-1324. doi: 10.3233/JAD-180514.   PMID: 30040735

Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK, Montine TJ, Schneider JA, Nelson PT.  The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses.  J Neuropathol Exp Neurol. 2018 Aug 1;77(8):717-726. doi: 10.1093/jnen/nly049.  PMID: 29945202

Welden JR, van Doorn J, Nelson PT, Stamm S.  The human MAPT locus generates circular RNAs.  Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2753-2760. doi: 10.1016/j.bbadis.2018.04.023. Epub 2018 May 3.  PMID: 29729314

Knopman DS, Haeberlein SB, Carrillo MC, Hendrix JA, Kerchner G, Margolin R, Maruff P, Miller DS, Tong G, Tome MB, Murray ME, Nelson PT, Sano M, Mattsson N, Sultzer DL, Montine TJ, Jack CR Jr, Kolb H, Petersen RC, Vemuri P, Canniere MZ, Schneider JA, Resnick SM, Romano G, van Harten AC, Wolk DA, Bain LJ, Siemers E.  The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.   Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002.   PMID: 29653607

Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D.  APOE DNA methylation is altered in Lewy body dementia.  Alzheimers Dement. 2018 Jul;14(7):889-894. doi: 10.1016/j.jalz.2018.02.005. Epub 2018 Mar 12.  PMID: 29544979

De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G.  BIN1 localization is distinct from Tau tangles in Alzheimer's disease.

Matters (Zur). 2017 Jan;2017. doi: 10.19185/matters.201611000018. Epub 2017 Jan 12.  PMID: 29479533 Pruzin JJ, Nelson PT, Abner EL, Arvanitakis Z.  Relationship of Type 2 Diabetes to Human Brain Pathology.  Neuropathol Appl Neurobiol. 2018 Feb 8. doi: 10.1111/nan.12476. PMID: 29424027

Al-Janabi OM, Panuganti P, Abner EL, Bahrani AA, Murphy R, Bardach SH, Caban-Holt A, Nelson PT, Gold BT, Smith CD, Wilcock DM, Jicha GA.  Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities.  J Neuroimaging. 2018 Jan 5. doi: 10.1111/jon.12494. [Epub ahead of print]  PMID: 29314393

Gal J, Chen J, Katsumata Y, Fardo DW, Wang WX, Artiushin S, Price D, Anderson S, Patel E, Zhu H, Nelson PT*.  Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.  J Neuropathol Exp Neurol. 2018 Jan 1;77(1):21-39. doi: 10.1093/jnen/nlx097.  PMID: 29186589

Nelson PT*, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, Van Eldik LJ, Jicha GA, Gal Z, Nelson RS, Nelson BG, Gal J, Azam MT, Fardo DW, Cykowski MD.  The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.  J Neuropathol Exp Neurol. 2018 Jan 1;77(1):2-20. doi: 10.1093/jnen/nlx099. PMID: 29186501

Book & Book Chapters:

Nelson, PT and Neltner, J.H., Pathology of Brain aging (Chapter 1), in Neurodegeneration, Eds--Anthony Schapira MD, DSc, FRCP, FMedSci, Zbigniew Wszolek MD, Ted M. Dawson MD, PhD and Nicholas Wood FRCP, PhD, FMedSci, 2017 John Wiley and Sons.

J. Pruzin, Jeremy & T. Nelson, Peter & Abner, Erin & Arvanitakis, Zoe. (2018). Neuropathological Insights Into the Link Between Type 2 Diabetes and Dementia. 10.1016/B978-0-12-809454-9.00006-8.

Sponsored Research Projects, Grants, & Contract Activities:

Co-Investigator for funded research project entitled: Alzheimer’s Disease Core Center. (V. Eldik, PI)

Primary Investigator for funded research project entitled: Novel Pathogenetic Mechanism for Hippocampal Sclerosis, A Common Alzheimer’s Mimic. (P. Nelson, PI)