Peter Nelson, MD, PhD

Publications & Other Scholarly Work:

1     Shade LM, Katsumata Y, Hohman TJ, Nho K, Saykin AJ, Mukherjee S, Boehme KL, Kauwe JS, Farrer LA, Schellenberg GD, Haines JL, Mayeux RP, Schneider JA, Nelson PT, Fardo DW. Genome-wide association study of brain arteriolosclerosis. J Cereb Blood Flow Metab. 2022 Feb 14. doi: 10.1177/0271678X211066299. Online ahead of print. PMID: 35156446

2     Gauthreaux KM, Teylan MA, Katsumata Y, Mock C, Culhane JE, Chen YC, Chan KCG, Fardo DW, Dugan AJ, Cykowski MD, Jicha GA, Kukull WA, Nelson PT. Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis. Neurology. 2022 Feb 4. doi: 10.1212/WNL.0000000000200001. Online ahead of print. PMID: 35121671

3     Karanth SD, Katsumata Y, Nelson PT, Fardo DW, McDowell JK, Schmitt FA, Kryscio RJ, Browning SR, Braithwaite D, Arnold SM, Abner EL. Cancer diagnosis is associated with a lower burden of dementia and less Alzheimer's-type neuropathology. Brain. 2022 Jan 30. doi: 10.1093/brain/awac035. Online ahead of print. PMID: 35094057

4     Wang R, Chopra N, Nho K, Maloney B, Obukhov AG, Nelson PT, Counts SE, Lahiri DK. Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer's biomarkers. Mol Psychiatry. 2022 Jan 27. doi: 10.1038/s41380-021-01351-3. Online ahead of print. PMID: 35087196

5     Gal J, Katsumata Y, Zhu H, Srinivasan S, Chen J, Johnson LA, Wang WX, Golden LR, Wilcock DM, Jicha GA, Cykowski MD, Nelson PT. Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele. Am J Pathol. 2021 Dec 24. doi: 10.1016/j.ajpath.2021.11.013. Online ahead of print. PMID: 34954207

6     Hawkinson TR, Clarke HA, Young LEA, Conroy LR, Markussen KH, Kerch KM, Johnson LA, Nelson PT, Wang C, Allison DB, Gentry MS, Sun RC. In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains. Alzheimers Dement. 2021 Dec 15. doi: 10.1002/alz.12523. Online ahead of print. PMID: 34908231

7     Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Teylan MA, Boehme KL, Mukherjee S, Kauwe JSK, Hohman TJ, Schneider JA, Fardo DW; Alzheimer's Disease Genetics Consortium. Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes. Neurobiol Aging. 2022 Mar;111:95-106. doi: 10.1016/j.neurobiolaging.2021.10.011. Epub 2021 Oct 29. PMID: 34852950

8     Srinivasan S, Gal J, Bachstetter A, Nelson PT. Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease. Neuropathol Appl Neurobiol. 2022 Feb;48(2). doi: 10.1111/nan.12776. Epub 2021 Dec 7. PMID: 34820873

9     Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 Jan;143(1):33-53. doi: 10.1007/s00401-021-02379-z. Epub 2021 Nov 1. PMID: 34719765

10   Teylan MA, Mock C, Gauthreaux K, Culhane JE, Jicha G, Chen YC, Chan KCG, Kukull WA, Nelson PT, Katsumata Y. Differences in Symptomatic Presentation and Cognitive Performance Among Participants With LATE-NC Compared to FTLD-TDP. J Neuropathol Exp Neurol. 2021 Nov 19;80(11):1024–1032. doi: 10.1093/jnen/nlab098. Epub 2021 Oct 1. PMID: 34597386

11   Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Boehme KL, Teylan MA, Cykowski MD, Mukherjee S, Kauwe JSK, Hohman TJ, Schneider JA; Alzheimer’s Disease Genetics Consortium, Fardo DW. Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta Neuropathol Commun. 2021 Sep 15;9(1):152. doi: 10.1186/s40478-021-01250-2. PMID: 34526147

12   Wu X, Peng C, Nelson PT, Cheng Q. Random forest-integrated analysis in AD and LATE brain transcriptome-wide data to identify disease-specific gene expression. PLoS One. 2021 Sep 7;16(9). doi: 10.1371/journal.pone.0256648. eCollection 2021. PMID: 34492068

13   Kloske CM, Dugan AJ, Weekman EM, Winder Z, Patel E, Nelson PT, Fardo DW, Wilcock DM. Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status. J Neuropathol Exp Neurol. 2021 Oct 26;80(10):922-932. doi: 10.1093/jnen/nlab085. PMID: 34486652

14   Nelson PT. LATE Neuropathologic Changes with Little or No Alzheimer Disease is Common and is Associated with Cognitive Impairment but Not Frontotemporal Dementia. J Neuropathol Exp Neurol. 2021 Aug 11;80(7):649-651. doi: 10.1093/jnen/nlab050. PMID: 34270750

15   Niedowicz DM, Wang WX, Price DA, Nelson PT. Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes. J Thyroid Res. 2021 Jun 24. doi: 10.1155/2021/9960188. eCollection 2021. PMID: 34257897

16   Nelson PT. What to do with unusual TDP-43 proteinopathy cases? Neuropathol Appl Neurobiol. 2022 Feb;48(1). doi: 10.1111/nan.12745. Epub 2021 Jul 13. PMID: 34164840

17   Karanth SD, Schmitt FA, Nelson PT, Katsumata Y, Kryscio RJ, Fardo DW, Harp JP, Abner EL. Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.  J Alzheimers Dis. 2021 May 28. doi: 10.3233/JAD-210293. PMID: 34057090

18   Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A.Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.  J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. PMID: 34037669

19   Bachstetter AD, Garrett FG, Jicha GA, Nelson PT.  Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review.  Acta Neuropathol Commun. 2021 Mar 23;9(1):49. doi: 10.1186/s40478-021-01152-3. PMID: 33757579

20   Kelly SC, Nelson PT, Counts SE.  Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort.  J Neuropathol Exp Neurol. 2021 Mar 22;80(4):325-335. doi: 10.1093/jnen/nlab017. PMID: 33709107

21   Ly H, Verma N, Sharma S, Kotiya D, Despa S, Abner EL, Nelson PT, Jicha GA, Wilcock DM, Goldstein LB, Guerreiro R, Brás J, Hanson AJ, Craft S, Murray AJ, Biessels GJ, Troakes C, Zetterberg H, Hardy J, Lashley T, Aesg, Despa F. The association of circulating amylin with β-amyloid in familial Alzheimer's disease. Alzheimers Dement (N Y). 2021 Jan 20;7(1):e12130. doi: 10.1002/trc2.12130  PMID: 33521236

22   Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, Price D, Nelson PT, Bachstetter AD. Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.  Neurobiol Aging. 2021 Jan 6;99:19-27. doi: 0.1016/j.neurobiolaging.2020.12.003.  PMID: 33422891

23   Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, Polvikoski T, Sikorska B, Smith C, Grinberg LT, Thal DR, Trojanowski JQ, McKeith IG.Acta Neuropathol. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. 2021 Jan 5. doi: 10.1007/s00401-020-02255-2. PMID: 33399945

24   Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, Han ZT, Zhang HH, Wang WX, Nelson PT, Chen JG, Lu Y, Man HY, Liu D, Zhu LQ. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease.  Cell Death Differ. 2021 Jan 4. doi: 10.1038/s41418-020-00685-9. PMID: 33398092

25   Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.   J Neuropathol Exp Neurol. 2021 Jan 20;80(2):102-111. doi: 10.1093/jnen/nlaa153.PMID: 33367843

26   Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT*.  Brain arteriolosclerosis. Acta Neuropathol. 2021 Jan;141(1):1-24. doi: 10.1007/s00401-020-02235-6. PMID: 33098484

27   Robinson JL, Porta S, Garrett FG, Zhang P, Xie SX, Suh E, Van Deerlin VM, Abner EL, Jicha GA, Barber JM, Lee VM, Lee EB, Trojanowski JQ, Nelson PT*. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration. Brain. 2020 Sep 1;143(9):2844-2857. doi: 10.1093/brain/awaa219.  PMID: 32830216

28   Katsumata Y, Abner EL, Karanth S, Teylan MA, Mock CN, Cykowski MD, Lee EB, Boehme KL, Mukherjee S, Kauwe JSK, Kryscio RJ, Schmitt FA, Fardo DW, Nelson PT*.  Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy. Acta Neuropathol. 2020 Nov;140(5):659-674. doi: 10.1007/s00401-020-02211-0. Epub 2020 Aug 14. PMID: 32797255 Free PMC article.

29   Nelson BG, Patel E, Arth D, Nelson PT.  Embedding Brain Tissue for Routine Histopathology: A Processing Step Worthy of Consideration in the Digital Pathology Era. Appl Immunohistochem Mol Morphol. 2020 Nov/Dec;28(10):791-793. doi: 10.1097/PAI.0000000000000832. PMID: 32773433 Smith CD, Van Eldik LJ, Jicha GA, Schmitt FA, Nelson PT, Abner EL, Kryscio RJ, Murphy RR, Andersen AH.  Brain structure changes over time in normal and mildly impaired aged persons.  AIMS Neurosci. 2020 May 20;7(2):120-135. doi: 10.3934/Neuroscience.2020009. PMID: 32607416

30   Karanth S, Nelson PT, Katsumata Y, Kryscio RJ, Schmitt FA, Fardo DW, Cykowski MD, Jicha GA, Van Eldik LJ, Abner EL.  Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults.  JAMA Neurol. 2020 Jun 22:e201741. doi: 10.1001/jamaneurol.2020.1741.  PMID: 32568358

31   Schindler SE, Jicha GA, Nelson PT, Keene CD, Blennow K, Molinuevo JL, Masters CL, Hansson O, Teunissen CE, Galasko D, Shaw LM, Levey AI, Silverberg N.  Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19.  J Alzheimers Dis. 2020;76(1):27-31. doi: 10.3233/JAD-200684.  PMID: 32568212

32   Prajapati P, Wang WX, Nelson PT, Springer JE. Methodology for Subcellular Fractionation and MicroRNA Examination of Mitochondria, Mitochondria Associated ER Membrane (MAM), ER, and Cytosol from Human Brain. Methods Mol Biol. 2020;2063:139-154. doi: 10.1007/978-1-0716-0138-9_11. PubMed PMID: 31667768.

33   Nelson PT*, Fardo DW, Katsumata Y.  The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review.  J Neuropathol Exp Neurol. 2020 Jun 1;79(6):568-584. doi: 10.1093/jnen/nlaa024.  PMID: 32357373

34   Mock C, Teylan M, Beecham G, Besser L, Cairns NJ, Crary JF, Katsumata Y, Nelson PT, Kukull W.  The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions.  Alzheimer Dis Assoc Disord. 2020 Apr-Jun;34(2):105-111. doi: 10.1097/WAD.0000000000000380.   PMID: 32304374

35   Winder Z, Sudduth TL, Fardo D, Cheng Q, Goldstein LB, Nelson PT, Schmitt FA, Jicha GA, Wilcock DM.  Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers. Front Neurosci. 2020 Feb 6;14:84. doi: 10.3389/fnins.2020.00084. eCollection 2020.  PMID: 32116527 Free PMC article.

36   Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang WX, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT. Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene. J Neuropathol Exp Neurol. 2020 Jan 1;79(1):3-21. doi: 10.1093/jnen/nlz116. PubMed PMID: 31748784.

37   Besser LM, Teylan MA, Nelson PT. Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations. J Neuropathol Exp Neurol. 2019 Nov 28;. doi: 10.1093/jnen/nlz126. [Epub ahead of print] PubMed PMID: 31845964.

38   Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.  Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.  Brain. 2019 Apr 30. pii: awz099. doi: 10.1093/brain/awz099.

39   Abner EL, Nelson PT, Jicha GA, Cooper GE, Fardo DW, Schmitt FA, Kryscio RJ.  Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis.  J Alzheimers Dis. 2019;68(2):625-633. doi: 10.3233/JAD-181119.

40   Chornenkyy Y, Fardo DW, Nelson PT.  Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.  Lab Invest. 2019 Feb 11. doi: 10.1038/s41374-019-0196-y. [Epub ahead of print] Review.

41   Jicha GA, Nelson PT.  Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.  Continuum (Minneap Minn). 2019 Feb;25(1):208-233. doi: 10.1212/CON.0000000000000697.

42   Nelson PT, Gal Z, Wang WX, Niedowicz DM, Artiushin SC, Wycoff S, Wei A, Jicha GA, Fardo DW.  TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.  Neurobiol Dis. 2019 May;125:67-76. doi: 10.1016/j.nbd.2019.01.013. Epub 2019 Jan 23.

43   Katsumata Y, Fardo DW, Kukull WA, Nelson PT.  Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.  Acta Neuropathol Commun. 2018 Dec 19;6(1):142. doi: 10.1186/s40478-018-0641-y.

44   Niedowicz DM, Özcan S, Nelson PT.  Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice.   J Diabetes Res. 2018 Oct 29;2018:1251345. doi: 10.1155/2018/1251345. eCollection 2018.

45   Katsumata Y, Nelson PT, Estus S; Alzheimer's Disease Neuroimaging Initiative (ADNI), Fardo DW. Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.   Neurobiol Aging. 2019 Feb;74:135-146. doi: 10.1016/j.neurobiolaging.2018.10.017. Epub 2018 Oct 23.

46   Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA.  Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.  J Alzheimers Dis. 2018;66(3):1095-1104. doi: 10.3233/JAD-180663.

47   Trieu T, Sajjadi SA, Kawas CH, Nelson PT, Corrada MM.  Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.   Neurology. 2018 Nov 6;91(19):e1788-e1798. doi: 10.1212/WNL.0000000000006455. Epub 2018 Oct 12.

48   Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.  Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.  Nat Neurosci. 2018 Oct;21(10):1482-1492. doi: 10.1038/s41593-018-0223-0. Epub 2018 Sep 17.  PMID: 30224808

49   Chornenkyy Y, Wang WX, Wei A, Nelson PT*.  Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline.  Brain Pathol. 2018 Aug 14. doi: 10.1111/bpa.12655. Review.  PMID: 30106209

50   Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM, Van Eldik LJ, Nelson PT*.  Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques.  J Alzheimers Dis. 2018;64(4):1307-1324. doi: 10.3233/JAD-180514.   PMID: 30040735

51   Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK, Montine TJ, Schneider JA, Nelson PT.  The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses.  J Neuropathol Exp Neurol. 2018 Aug 1;77(8):717-726. doi: 10.1093/jnen/nly049.  PMID: 29945202

52   Welden JR, van Doorn J, Nelson PT, Stamm S.  The human MAPT locus generates circular RNAs.  Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2753-2760. doi: 10.1016/j.bbadis.2018.04.023. Epub 2018 May 3.  PMID: 29729314

53   Knopman DS, Haeberlein SB, Carrillo MC, Hendrix JA, Kerchner G, Margolin R, Maruff P, Miller DS, Tong G, Tome MB, Murray ME, Nelson PT, Sano M, Mattsson N, Sultzer DL, Montine TJ, Jack CR Jr, Kolb H, Petersen RC, Vemuri P, Canniere MZ, Schneider JA, Resnick SM, Romano G, van Harten AC, Wolk DA, Bain LJ, Siemers E.  The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.   Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002.   PMID: 29653607

54   Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D.  APOE DNA methylation is altered in Lewy body dementia.  Alzheimers Dement. 2018 Jul;14(7):889-894. doi: 10.1016/j.jalz.2018.02.005. Epub 2018 Mar 12.  PMID: 29544979

55   De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G.  BIN1 localization is distinct from Tau tangles in Alzheimer's disease.

56   Matters (Zur). 2017 Jan;2017. doi: 10.19185/matters.201611000018. Epub 2017 Jan 12.  PMID: 29479533 Pruzin JJ, Nelson PT, Abner EL, Arvanitakis Z.  Relationship of Type 2 Diabetes to Human Brain Pathology.  Neuropathol Appl Neurobiol. 2018 Feb 8. doi: 10.1111/nan.12476. PMID: 29424027

57   Al-Janabi OM, Panuganti P, Abner EL, Bahrani AA, Murphy R, Bardach SH, Caban-Holt A, Nelson PT, Gold BT, Smith CD, Wilcock DM, Jicha GA.  Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities.  J Neuroimaging. 2018 Jan 5. doi: 10.1111/jon.12494. [Epub ahead of print]  PMID: 29314393

58   Gal J, Chen J, Katsumata Y, Fardo DW, Wang WX, Artiushin S, Price D, Anderson S, Patel E, Zhu H, Nelson PT*.  Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.  J Neuropathol Exp Neurol. 2018 Jan 1;77(1):21-39. doi: 10.1093/jnen/nlx097.  PMID: 29186589

59   Nelson PT*, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, Van Eldik LJ, Jicha GA, Gal Z, Nelson RS, Nelson BG, Gal J, Azam MT, Fardo DW, Cykowski MD.  The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.  J Neuropathol Exp Neurol. 2018 Jan 1;77(1):2-20. doi: 10.1093/jnen/nlx099. PMID: 29186501

60   Nelson PT*, Wang WX, Janse SA, Thompson KL.  MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls.  Brain Res. 2018 Jan 1;1678:374-383. doi: 10.1016/j.brainres.2017.11.009. Epub 2017 Nov 13.  PMID: 29146111

61   Brenowitz WD, Han F, Kukull WA, Nelson PT.  Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.  Neurobiol Aging. 2018 Feb;62:64-71. doi: 10.1016/j.neurobiolaging.2017.10.004. Epub 2017 Nov 4.  PMID: 29107848

62   Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.  Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.  Aging Dis. 2017 May 2;8(3):257-266. doi: 10.14336/AD.2017.0112. eCollection 2017 May.

63   Ighodaro ET, Nelson PT*, Kukull WA, Schmitt FA, Abner EL, Caban-Holt A, Bardach SH, Hord DC, Glover CM, Jicha GA, Van Eldik LJ, Byrd AX, Fernander A.  Challenges and Considerations Related to Studying Dementia in African Americans.  J Alzheimers Dis. 2017 Jul 19. doi: 10.3233/JAD-170242. [Epub ahead of print]  PMID: 28731440

64   Ly H, Verma N, Wu F, Liu M, Saatman KE, Nelson PT, Slevin JT, Goldstein LB, Biessels GJ, Despa F.  Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.  Ann Neurol. 2017 Jul 11. doi: 10.1002/ana.24992. [Epub ahead of print]  PMID: 28696548

65   Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.   Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).  J Neuropathol Exp Neurol. 2017 Jun 7. doi: 10.1093/jnen/nlx041. [Epub ahead of print]  PMID: 28591867

66   Cykowski MD, Powell SZ, Schulz PE, Takei H, Rivera AL, Jackson RE, Roman G, Jicha GA, Nelson PT.  Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis.  Arch Pathol Lab Med. 2017 Aug;141(8):1113-1126. doi: 10.5858/arpa.2016-0469-SA. Epub 2017 May 3.  PMID: 28467211

67   Shen W, Nan C, Nelson PT, Ripps H, Slaughter MM.  GABAB receptor attenuation of GABAA currents in neurons of the mammalian central nervous system.   Physiol Rep. 2017 Mar;5(6). pii: e13129. doi: 10.14814/phy2.13129.   PMID: 28348006 Free PMC Article

68   Smith VD, Bachstetter AD, Ighodaro E, Roberts K, Abner EL, Fardo DW, Nelson PT*.  Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.  Brain Pathol. 2017 Mar 9. doi: 10.1111/bpa.12505. [Epub ahead of print]  PMID: 28281308

69   Berger JR, Miller CS, Danaher RJ, Doyle K, Simon KJ, Norton E, Gorelik L, Cahir-McFarland E, Singhal D, Hack N, Owens JR, Nelson PT, Neltner JH.Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA.   JAMA Neurol. 2017 Apr 1;74(4):437-444. doi: 10.1001/jamaneurol.2016.5537.   PMID: 28241186

70   Abner EL, Kryscio RJ, Schmitt FA, Fardo DW, Moga DC, Ighodaro ET, Jicha GA, Yu L, Dodge HH, Xiong C, Woltjer RL, Schneider JA, Cairns NJ, Bennett DA, Nelson PT.  Outcomes after diagnosis of mild cognitive impairment in a large autopsy series.   Ann Neurol. 2017 Apr;81(4):549-559. doi: 10.1002/ana.24903. Epub 2017 Mar 22.  PMID: 28224671

71   Fardo DW, Katsumata Y, Kauwe JS, Deming Y, Harari O, Cruchaga C; Alzheimer's Disease Neuroimaging Initiative, Nelson PT.  CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.   Exp Gerontol. 2017 Apr;90:83-89. doi: 10.1016/j.exger.2017.01.025. Epub 2017 Feb 9.   PMID: 28189700

72   Katsumata Y, Nelson PT, Ellingson SR, Fardo DW.  Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.   Neurobiol Aging. 2017 May;53:193.e17-193.e25. doi: 10.1016/j.neurobiolaging.2017.01.003. Epub 2017 Jan 9.   PMID: 28131462

73   Bachstetter AD, Ighodaro ET, Hassoun Y, Aldeiri D, Neltner JH, Patel E, Abner EL, Nelson PT.  Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.   Neurobiol Aging. 2017 Apr;52:98-105. doi: 10.1016/j.neurobiolaging.2016.12.028. Epub 2017 Jan 5.   PMID: 28131016

74   Flanagan ME, Marshall DA, Shofer JB, Montine KS, Nelson PT, Montine TJ, Keene CD.  Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.  J Neuropathol Exp Neurol. 2017 Jan 1;76(1):39-43. doi: 10.1093/jnen/nlw104.  PMID: 28062571

75   Dodge HH, Zhu J, Woltjer R, Nelson PT, Bennett DA, Cairns NJ, Fardo DW, Kaye JA, Lyons DE, Mattek N, Schneider JA, Silbert LC, Xiong C, Yu L, Schmitt FA, Kryscio RJ, Abner EL; SMART data consortium.   Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease.  Alzheimers Dement. 2017 Jun;13(6):613-623. doi: 10.1016/j.jalz.2016.11.003. Epub 2016 Dec 23.  PMID: 28017827

76   Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ.  Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.   Lancet Neurol. 2017 Jan;16(1):55-65. doi: 10.1016/S1474-4422(16)30291-5.  PMID: 27979356

77   Wang WX, Fardo DW, Jicha GA, Nelson PT.  A Customized Quantitative PCR MicroRNA Panel Provides a Technically Robust Context for Studying Neurodegenerative Disease Biomarkers and Indicates a High Correlation Between Cerebrospinal Fluid and Choroid Plexus MicroRNA Expression.  Mol Neurobiol. 2016 Nov 29. [Epub ahead of print]   PMID: 27900678

78   Furman JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, Nelson PT, Diamond MI.  Widespread tau seeding activity at early Braak stages.    Acta Neuropathol. 2017 Jan;133(1):91-100. doi: 10.1007/s00401-016-1644-z. Epub 2016 Nov 22.  PMID: 27878366

79   Nelson PT*, Katsumata Y, Nho K, Artiushin SC, Jicha GA, Wang WX, Abner EL, Saykin AJ, Kukull WA; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Fardo DW.  Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.  Acta Neuropathol. 2016 Dec;132(6):841-858. Epub 2016 Nov 4.  PMID: 27815632

80   Kryscio RJ, Abner EL, Nelson PT, Bennett D, Schneider J, Yu L, Hemmy LS, Lim KO, Masaki K, Cairns N, Xiong C, Woltjer R, Dodge HH, Tyas S, Fardo DW, Lou W, Wan L, Schmitt FA.  The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.  J Prev Alzheimers Dis. 2016 Jun;3(2):85-91.  PMID: 27709107 Pleiss MM, Sompol P, Kraner SD, Abdul HM, Furman JL, Guttmann RP, Wilcock DM, Nelson PT, Norris CM.  Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function.Biochim Biophys Acta. 2016 Sep;1862(9):1521-32. doi: 10.1016/j.bbadis.2016.05.007. Epub 2016 May 20.  PMID: 27212416

81   Nelson PT*.  Cerebrovascular pathology and Alzheimer's disease.  Lancet Neurol. 2016 Aug;15(9):895-6. doi: 10.1016/S1474-4422(16)30038-2. Epub 2016 Jun 14. PMID: 27312739

82   Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J.  miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).  Mol Neurodegener. 2016 Jul 26;11(1):55. doi: 10.1186/s13024-016-0121-4.  PMID: 27456084 F

83   Nelson PT*, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET.  "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).   J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98. doi: 10.1093/jnen/nlw033. Epub 2016 May 21. Review.  PMID: 27209644

84   Pietrzak M, Rempala GA, Nelson PT, Hetman M.  Non-random distribution of methyl-CpG sites and non-CpG methylation in the human rDNA promoter identified by next generation bisulfite sequencing.  Gene. 2016 Mar 20. pii: S0378-1119(16)30198-6. doi: 10.1016

85   Nho K, Saykin AJ; Disease Neuroimaging Initiative Alzheimer’s, Nelson PT*.  Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.  J Alzheimers Dis. 2016 Mar 15.   PMID: 27003218

86   Cykowski MD, Takei H, Van Eldik LJ, Schmitt FA, Jicha GA, Powell SZ, Nelson PT.  Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons.   J Neuropathol Exp Neurol. 2016 Mar 12. pii: nlw014.   PMID: 26971127

87   Smith CD, Johnson ES, Van Eldik LJ, Jicha GA, Schmitt FA, Nelson PT, Kryscio RJ, Murphy RR, Wellnitz CV.  Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease.  Brain Behav. 2016 Feb 16:e00438. PMID: 26925303

88   Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT.  Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.    Alzheimers Dement. 2016 Feb;12(2):164-9. doi: 10.1016/j.jalz.2015.07.492.   PMID: 26327235

89   Abner EL, Nelson PT, Kryscio RJ, Schmitt FA, Fardo DW, Woltjer RL, Cairns NJ, Yu L, Dodge HH, Xiong C, Masaki K, Tyas SL, Bennett DA, Schneider JA, Arvanitakis Z.  Diabetes is associated with cerebrovascular but not Alzheimer neuropathology.   Alzheimers Dement. 2016 Jan 23. pii: S1552-5260(15)03030-7. doi: 10.1016/j.jalz.2015.12.006. PMID: 26812281

90   Kim E, Wang B, Sastry N, Masliah E, Nelson PT, Cai H, Liao FF.    NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.   Hum Mol Genet. 2016 Jan 15;25(2):211-22. doi: 10.1093/hmg/ddv445. PMID: 26503960

91   Ighodaro ET, Abner EL, Fardo DW, Lin AL, Katsumata Y, Schmitt FA, Kryscio RJ, Jicha GA, Neltner JH, Monsell SE, Kukull WA, Moser DK, Appiah F, Bachstetter AD, Van Eldik LJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Nelson PT*.  Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.   J Cereb Blood Flow Metab. 2016 Jan 6. pii: 0271678X15621574. PMID: 26738751

92   Jiang Y, Huang H, Abner E, Broster LS, Jicha GA, Schmitt FA, Kryscio R, Andersen A, Powell D, Van Eldik L, Gold BT, Nelson PT, Smith C, Ding M.  Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States.  Front Aging Neurosci. 2016 Feb 8;8:15. doi: 10.3389/fnagi.2016.00015.   PMID: 26903858 FKovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW.  Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.   Acta Neuropathol. 2015 Dec 10.  PMID: 26659578

93   Neltner JH, Abner EL, Jicha GA, Schmitt FA, Patel E, Poon LW, Marla G, Green RC, Davey A, Johnson MA, Jazwinski SM, Kim S, Davis D, Woodard JL, Kryscio RJ, Van Eldik LJ, Nelson PT*.  Brain pathologies in extreme old age.   Neurobiol Aging. 2016 Jan;37:1-11. doi: 10.1016/j.neurobiolaging.2015.10.009. Epub 2015 Oct 19.   PMID: 26597697

94   Kim E, Wang B, Sastry N, Masliah E, Nelson PT, Cai H, Liao FF.  NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.  Hum Mol Genet. 2015 Oct 26. pii: ddv445.   PMID: 26503960 Free ArticleMeier S, Bell M, Lyons DN, Ingram A, Chen J, Gensel JC, Zhu H, Nelson PT, Abisambra JF.  Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.  J Alzheimers Dis. 2015 Sep 3.  PMID: 26402096

95   Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT.   Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.  Alzheimers Dement. 2015 Aug 29. pii: S1552-5260(15)02669-2. doi: 10.1016/j.jalz.2015.07.492.  PMID: 26327235

96   Brenowitz WD, Nelson PT, Besser LM, Heller KB, Kukull WA.  Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes.  Neurobiol Aging. 2015 Oct;36(10):2702-8. doi: 10.1016/j.neurobiolaging.2015.06.028. PMID: 26239176

97   Nelson PT*, Jicha GA, Wang WX, Ighodaro E, Artiushin S, Nichols CG, Fardo DW.  ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.    Ageing Res Rev. 2015 Jul 28. pii: S1568-1637(15)30009-X. doi: 10.1016/j.arr.2015.07.007. PMID: 26226329

98   Nelson PT*, Wang WX, Wilfred BR, Wei A, Dimayuga J, Huang Q, Ighodaro E, Artiushin S, Fardo DW.  Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.   J Neurochem. 2015 Sep;134(6):1026-39. doi: 10.1111/jnc.13202. PMID: 26115089

99   Ighodaro ET, Jicha GA, Schmitt FA, Neltner JH, Abner EL, Kryscio RJ, Smith CD, Duplessis T, Anderson S, Patel E, Bachstetter A, Van Eldik LJ, Nelson PT*.  Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature.    J Neuropathol Exp Neurol. 2015 Jul;74(7):642-52. PMID: 26083567

100 achstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, Patel E, Abner EL, Kryscio RJ, Nelson PT.  Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.  Acta Neuropathol Commun. 2015 May 23;3(1):32.   PMID: 26001591

101 Abner EL, Schmitt FA, Nelson PT, Lou W, Wan L, Gauriglia R, Dodge HH, Woltjer RL, Yu L, Bennett DA, Schneider JA, Chen R, Masaki K, Katz MJ, Lipton RB, Dickson DW, Lim KO, Hemmy LS, Cairns NJ, Grant E, Tyas SL, Xiong C, Fardo DW, Kryscio RJ.  The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia.   Obs Stud. 2015 Mar;1(2015):56-73.   PMID: 25984574

102 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR Jr, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, Montine TJ, Nelson PT, Schmitt F, Schneider JA, Serrano-Pozo A, Thal DR, Toledo JB, Trojanowski JQ, Troncoso JC, Vonsattel JP, Wisniewski T.  PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.  Acta Neuropathol. 2015 May;129(5):757-62. doi: 10.1007/s00401-015-1407-2. Epub 2015 Mar 17. No abstract available.    PMID: 25778618

103 Nelson PT*, Jicha GA.  Cerebrospinal fluid vascular endothelial growth factor.  JAMA Neurol. 2015 May 1;72(5):502-3. doi: 10.1001/jamaneurol.2015.34. PMID: 25751033

104 Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I.  Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Feb 23. pii: 201420955. PMID: 25713380

105 Josephs KA, Nelson PT.  Unlocking the mysteries of TDP-43.  Neurology. 2015 Feb 4. pii: 10.1212/WNL.0000000000001322. PMID: 25653288

106 Katsumata Y, Mathews M, Abner EL, Jicha GA, Caban-Holt A, Smith CD, Nelson PT, Kryscio RJ, Schmitt FA, Fardo DW.  Assessing the discriminant ability, reliability, and comparability of multiple short forms of the Boston naming test in an Alzheimer's disease center cohort.  Dement Geriatr Cogn Disord. 2015;39(3-4):215-27. doi: 10.1159/000370108. Epub 2015 Jan 21. PMID: 25613081

107 Wang WX, Visavadiya NP, Pandya JD, Nelson PT, Sullivan PG, Springer JE.  Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury.  Exp Neurol. 2015 Mar;265:84-93. doi: 10.1016/j.expneurol.2014.12.018. Epub 2015 Jan 3.  PMID: 25562527 [PubMed - in process]

108 Nelson PT*, Wang WX, Partch AB, Monsell SE, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang LS, Kukull WA, Fardo DW.  Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.  J Neuropathol Exp Neurol. 2015 Jan;74(1):75-84. doi: 10.1097/NEN.0000000000000151.  PMID: 25470345

109 Attems J, Neltner JH, Nelson PT.  Quantitative neuropathological assessment to investigate cerebral multi-morbidity.  Alzheimers Res Ther. 2014 Nov 28;6(9):85. doi: 10.1186/s13195-014-0085-y. eCollection 2014.  PMID: 25435922

110 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT*.  Primary age-related tauopathy (PART): a common pathology associated with human aging.  Acta Neuropathol. 2014 Oct 28.

111 Kryscio RJ, Abner EL, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Self-reported memory complaints: Implications from a longitudinal cohort with autopsies.  Neurology. 2014 Oct 7;83(15):1359-65.

112 Gold BT, Zhu Z, Brown CA, Andersen AH, LaDu MJ, Tai L, Jicha GA, Kryscio RJ, Estus S, Nelson PT, Scheff SW, Abner E, Schmitt FA, Van Eldik LJ, Smith CD.  White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.  Neurobiol Aging. 2014 Oct;35(10):2263-71.

113 Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ.  Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.  Front Genet. 2014 Apr 23;5:88. PMID: 24795750

114 Nelson PT*, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE; Alzheimer’ Disease Genetic Consortium, Schellenberg GD, Fardo DW.  ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.  Acta Neuropathol. 2014 Apr 27.

115 Wang WX, Danaher RJ, Miller CS, Berger JR, Nubia VG, Wilfred BS, Neltner JH, Norris CM, Nelson PT*.   Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells.  Genomics Proteomics Bioinformatics. 2014 Jan 27.

116 Scheff SW, Neltner JH, Nelson PT*.  Is synaptic loss a unique hallmark of Alzheimer's disease?  Biochem Pharmacol. 2014 Jan 9.

117 Abner EL, Nelson PT, Schmitt FA, Browning SR, Fardo DW, Wan L, Jicha GA, Cooper GE, Smith CD, Caban-Holt AM, Van Eldik LJ, Kryscio RJ.  Self-Reported Head Injury and Risk of Late-Life Impairment and AD Pathology in an AD Center Cohort.  Dement Geriatr Cogn Disord. 2013 Dec 31;37(5-6):294-306.

118 Hallgren J, Pietrzak M, Rempala G, Nelson PT, Hetman M.  Neurodegeneration-associated instability of ribosomal DNA.  Biochim Biophys Acta. 2014 Jan 2.

119 Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT*.  Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing.  Brain. 2014 Jan;137(Pt 1):255-67.

120 Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT*.  Hippocampal Sclerosis of Aging is a Key Alzheimer's Disease Mimic: Clinical-Pathologic Correlations and Comparisons with both Alzheimer's Disease and Non-Tauopathic Frontotemporal Lobar Degeneration. J Alzheimers Dis. 2013 Nov 22.

121 Dorval V, Nelson PT, Hébert SS.  Circulating microRNAs in Alzheimer's disease: the search for novel biomarkers.  Front Mol Neurosci. 2013 Aug 30;6:24. doi: 10.3389/fnmol.2013.00024. Review. PMID: 24009553

122 Malik M, Simpson JF, Parikh I, Wilfred BR, Fardo DW, Nelson PT, Estus S.  CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.   J Neurosci. 2013 Aug 14;33(33):13320-5.  PMID: 23946390

123 Nelson PT*, Smith CD, Abner EL, Wilfred BJ, Wang WX, Neltner JH, Baker M, Fardo DW, Kryscio RJ, Scheff SW, Jicha GA, Jellinger KA, Van Eldik LJ, Schmitt FA.  Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease.  Acta Neuropathol. 2013 Aug;126(2):161-77.

124 Johnson EJ, Vishwanathan R, Johnson MA, Hausman DB, Davey A, Scott TM, Green RC, Miller LS, Gearing M, Woodard J, Nelson PT, Chung HY, Schalch W, Wittwer J, Poon LW.  Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study.  J Aging Res. 2013;2013:951786.

125 Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW.  APOE-e2 and APOE-e4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature. J Neuropathol Exp Neurol. 2013 Jul;72(7):708-15.

126 Kryscio RJ, Abner EL, Lin Y, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA.Adjusting for Mortality when Identifying Risk Factors for Transitions to Mild Cognitive Impairment and Dementia.  J Alzheimers Dis. 2013 Mar 18

127 Nicholson AM, Baker MC, Finch NA, Rutherford NJ, Wider C, Graff-Radford NR, Nelson PT, Clark HB, Wszolek ZK, Dickson DW, Knopman DS, Rademakers R.  CSF1R mutations link POLD and HDLS as a single disease entity.  Neurology. 2013 Feb 13.

128 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP.  APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies.  JAMA Neurol. 2013 Feb;70(2):223-8.

129 Hébert SS, Wang WX, Zhu Q, Nelson PT*.A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer's Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls.  J Alzheimers Dis. 2013 Feb 12.

130 Neltner JH, Abner EL, Schmitt FA, Denison SK, Anderson S, Patel E, Nelson PT. Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes. J Neuropathol Exp Neurol. 2012 Dec;71(12):1075-85.

131 Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM.  Neuroinflammatory phenotype in early Alzheimer's disease.  Neurobiol Aging. 2012 Oct 9.

132 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Trojanowski JQ, Schellenberg GD, Yearout D, Huston H, Fritts-Penniman A, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP.  GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology. 2012 Nov 6;79(19):1944-1950.

133 Santa-Maria I, Haggiagi A, Liu X, Wasserscheid J, Nelson PT, Dewar K, Clark LN, Crary JF. The MAPT H1 haplotype is associated with tangle-predominant dementia.  Acta Neuropathol. 2012 Jul 17.

134 Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA..Mild cognitive impairment: statistical models of transition using longitudinal clinical data.  Int J Alzheimers Dis. 2012;2012:291920. Epub 2012 Mar 25.

135 Nelson PT*, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG.  Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature.  J Neuropathol Exp Neurol. 2012 May;71(5):362-81. Review.

136 Schmitt FA, Nelson PT, Abner E, Scheff S, Jicha GA, Smith C, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Caban-Holt A, Lovell MA, Kryscio RJ.University of kentucky sanders-brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology.  Curr Alzheimer Res. 2012 Jul 1;9(6):724-33.

137 Rinker B, Fink BF, Stoker AR, Milan ME, Nelson PT..Calcium Channel Blockers Reduce the Effects of Cigarette Smoking on Peripheral Nerve Ischemia/Reperfusion Injury.  Ann Plast Surg. 2012 Mar 6.

138 Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ..National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease.  Alzheimers Dement. 2012 Jan;8(1):1-13.

139 Geekiyanage H, Nelson PT, Jicha GA, Chan C, Blood serum miRNA: Non-invasive biomarkers for Alzheimer’s disease.  Exp Neurol. 2012 Jun;235(2):491-6.

140 Hebert, SS, Nelson PT*.  Studying microRNAs in the brain: technical lessons learned from the first ten years.  Exp Neurol. 2012 Jun;235(2):397-401.

141 Grondin R,  Kaytor M, Ai Y, Nelson PT, Thakker D, Heisel J, Weatherspoon M, Blum J, Burright E, Zhang Z, Kaemmerer W.  Six-month Partial Suppression of Huntingtin is Well-tolerated in the Adult Rhesus Brain.  Brain. 2012 Apr;135(Pt 4):1197-209.

142 Stiles D, Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, Nechev L, Manoharan M, Kaemmerer WF, Gwost D, Steward GR, Gash DM, Sah DWY.  Widespread Suppression of Huntingtin with Convection-Enhanced Delivery of siRNA.  Exp Neurol, In Press.

143 Montine T, Beach T, Bigio E, Cairns N, Dickson DW, Duyckaerts C, Frosch M, Masliah E, Mirra SS, Nelson PT, Phelps A, Schneider JA, Trojanowski JQ, Vinters HV, and Hyman BT.  National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach.  Acta Neuropathologica.  2011, In Press.

144 Niedowicz DM, Nelson PT, Murphy MP.Alzheimer’s Disease: Pathological Mechanisms and Recent Insights.  Curr Neuropharmacol In Press 2011

145 Schmitt FA, Nelson PT, Abner A, Scheff SA, Jicha GA, Smith CD, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Kryscio RJ. University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures, and Neuropathology.  Alz Dis Assoc Disord. In Press 2011

146 Jicha, GA and Nelson, PT.  Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options.  Neurodegen Dis Management, 2011 Apr;1(2):141-156. 

147 Santacruz KS, Sonnen JA, Pezhouh MK, Desrosiers MF, Nelson PT, and Tyas SL. Alzheimer’s disease pathology without dementia in two longitudinal studies of aging: The Nun Study and the Adult Changes in Thought Study. J Neuropathol Exp Neurol, 2011 Oct;70(10):832-40.

148 Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, and Nelson PT*.  Preclinical AD Workgroup staging: pathological correlates and potential challenges.  Neurobiol Aging 2011 Apr 18. [Epub ahead of print]

149 Pietrzak M, Rempala G, Nelson PT, Zheng, J-J, Hetman, M.  Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease. PLOS One. 2011;6(7):e22585. Epub 2011

150 Rapoport, SI, Nelson PT. Biomarkers and Evolution in Alzheimer’s disease. Progress in Neurobiol.  2011 Epub Jul 23.

151 Saing T, Dick M, Nelson PT, Kim R, Cribbs DH, and Head E.  Frontal Cortex Neuropathology in Dementia Pugilistica.  J. Neurotrauma, 2011 Oct 21. [Epub ahead of print]

152 Nelson PT*, Wang WX, Mao G, Wilfred BR, Xie K, Jennings MH, Gao Z, Wang X.  Specific sequence determinants of miR-15/107 microRNA gene group targets.  Nucleic Acids Res.  2011 Oct;39(18):8163-72.. 

153 Nelson PT*, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW.  Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.  Acta Neuropathol. 2011 May; 121(5):571-87.

154 Nelson, PT*, Schmitt, FA, Lin, Y, Abner, EL, Jicha, GA, Patel, E, Thomason, PC, Neltner, JH, Smith, CD, Santacruz, KS, Sonnen, JA, Poon, LW, Gearing, M, Green, RC, Woodard, JL, Van Eldik, LJ, Kryscio, RJ,   Hippocampal sclerosis in advanced age: clinical and pathological features in 106 cases  Brain, 2011 May;134(5):1506-18.

155 Abner, EL, Kryscio, RJ, Schmitt, FA, Santacruz, KS, Jicha, GA, Lin, Y, Neltner JH, Smith, CD, Van Eldik, LJ, Nelson, PT*, “End-stage” neurofibrillary tangle pathology in preclinical Alzheimer’s disease—fact or fiction?, J Alzheimer's Disease, 2011 25(3):445-53.

156 Riley, KP, Jicha, GA, Davis, D, Abner, EL, Cooper, GE, Stiles, N, Smith, CD, Kryscio, RJ, Nelson, PT, Van Eldik LJ, and Schmitt, FA, Prediction of preclinical Alzheimer’s disease: Longitudinal rates of change in cognition, J Alzheimer's Disease, 2011 25(4):707-17.

157 Runker B, Fink BF, Barry NG, Fife JA, Milan ME, Stoker AR, Nelson PT, The effect of cigarette smoking on functional recovery following peripheral nerve ischemia/reperfusion injury, Microsurgery Journal, 2011 31(1):59-65.

158 Madathil SK, Nelson PT*, Saatman KE, Wilfred BR, MicroRNAs in CNS injury: potential roles and therapeutic implications, Bioessays, 2011 33(1):21-6.

159 Wang WX, Huang Q, Hu Y, Stromberg AJ, Nelson PT*.  Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter.  Acta Neuropathol. 2010 Oct 10.

160 Wang WX, Kyprianou N, Wang X, Nelson PT*. Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group. Cancer Res. 2010 70(22):9137-42.

161 Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, Nelson PT*. The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.  J Mol Biol. 2010 Sep 24;402(3):491-509.

162 Nelson PT*, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR.  Association between male gender and cortical Lewy body pathology in large autopsy series.  J Neurol. 2010

163 Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT*.  miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease.  Am J Pathol. 2010 Jul;177(1):334-45.

164 Wang WX, Wilfred BR, Xie K, Jennings MH, Hu Y, Stromberg AJ, Nelson PT*.  Individual microRNAs (miRNAs) display distinct mRNA targeting "rules"    RNA Biol. 2010 May 5;7(3).

165 Nelson PT*, Kukull WA, Frosch MP.  Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations. JNEN. 2010 May;69(5):449-54

166 Nelson PT*, Wang WX.  MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study.  J Alzheimers Dis. 2010

167 Nelson PT*, Kiriakidou M, Mourelatos Z, Tan GS, Jennings MH, Xie K, Wang WX.  High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain.  Brain Res. 2010 Jun 18;1338:122-30.

168 Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient.  Cary LC, Maul E, Potter C, Wong P, Nelson PT, Given C 2nd, Robertson W Jr.  Pediatrics. 2010 Mar;125(3):e699-703.

169 Nelson PT*, Dimayuga J, Wilfred, BR, MicroRNA in situ hybridization in the human entorhinal and transentorhinal cortex.  Front Hum Neurosci, 2010

170 Wang W-X, Wilfred BR, Hu Y, Stromberg AJ, Nelson PT*, Argonaute co-immunoprecipitation with RIP-CHIP show that miRNA transfection alter global patterns of mRNA recruitment to microribonucleoprotein complexes.  RNA,  2010.

171 Nelson PT*, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR.  Low sensitivity in clinical diagnoses of dementia with Lewy bodies.  J Neurol. 2009 Oct 1.

172 Nelson, PT*, Kryscio, RJ, Jicha, GA, Abner, EL, Schmitt, FA, Xu, L, Cooper, G, Smith, CD, Markesbery, WR, Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies, Neurology (2009)

173 Nelson, PT*, Kryscio, RJ, Jicha, GA, Abner, EL, Schmitt, FA, Xu, L, Cooper, G, Smith, CD, Markesbery, WR, Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.  J Neuropathol Exp Neurol. 2009 Jul;68(7):774-84

174 Berger JR, Fee DB, Nelson P, Nuovo G. Coxsackie B meningoencephalitis in a patient with acquired immunodeficiency syndrome and a multiple sclerosis-like illness.  J Neurovirol. 2009 May 14:1-6.

175 Berger JR, Dillon DA, Young BA, Goldstein SJ, Nelson P  Cystinosis of the brain and spinal cord with associated vasculopathy.  J Neurol Sci. 2009 Sep 15;284(1-2):182-5. Epub 2009 Apr 22.

176 Nelson PT*, Wilfred BR.  In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain.  Neurosci Lett. 2009 Apr 23.

177 Nelson PT*, Abner, EA, Scheff, SW, Schmitt, FA, Kryscio, RJ, Jicha, GA, Smith, CD, Patel, E, Markesbery, WR, Alzheimer pathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment.  Neurosci Letters, 2009.

178 Nelson PT*, Braak H, and Markesbery WR, Neuropathology and Cognitive Impairment in Alzheimer’s Disease: A Complex but Coherent Relationship.  J Neuropathol Exp Neurol. 2009 Jan;68(1):1-14.

179 Nelson PT*, Abner, EA, Schmitt, FA, Kryscio, RJ, Jicha, GA, Smith, CD, Davis, DG, Poduska, JW, Patel, E, Mendiondo, MS, Markesbery, WR, Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol, (In Press).

180 Jicha, GA, Schmitt, FA, Abner, EL, Nelson, PT, Cooper, GE, Smith, CD, and Markesbery, WR, Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease.  Neurobiol Aging, 2008

181 Nelson PT*, Smith, CD, Abner, EA, Schmitt, FA, Scheff, SW, Davis, GD, Keller, JN, Jicha, GA, Davis, D, Wang, W-X, Hartman, A, Katz, DG, and Markesbery WR, Human cerebral neuropathology of Type 2 diabetes mellitus.  BBA-Mol Basis of Disease, 2008

182 Nelson PT*, Kryscio, RJ, Abner, EA, Schmitt, FA, Jicha, GA, Mendiondo, MS, Cooper, G, Smith, CB, and Markesbery, WR,  Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer’s disease and AD+DLB.  J Alzheim Dis, 2008

183 Nelson PT*, Wang WX, Wilfred BR, Tang G.  Technical variables in high-throughput miRNA expression profiling: Much work remains to be done.  Biochim Biophys Acta. 2008 Apr 7.

184 Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT.  Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.  Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5614-9.

185 Wang WX, Wilfred BR, Baldwin DA, Isett RB, Ren N, Stromberg A, Nelson PT*.  Focus on RNA isolation: Obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue.  Biochim Biophys Acta. 2008 Feb 13.

186 Wang, W-X, Nelson PT, and Tang, G, RNA interference and miRNA pathways: mechanisms and protein machinery.  Wiley Encyclopedia of Chemical Biology.  2008

187 Wang W-X, Rajeev, BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, and Nelson PT*.  The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of BACE1.  J Neuroscience 2008 28(5): 1213-23.

188 Nelson PT*, Wang, W-X, and Rajeev, BW.  MicroRNAs in neurodegeneration.  Brain Pathology 2008 18(1): 130-8.

189 Nelson PT*, Jicha, GA, Schmitt, FA, Liue, H, Davis, DG, Mendiondo, MS, Abner, EL, and Markesbery, WR, Clinicopathological correlations in a large Alzheimer Disease Center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol. 2007 Dec; 66(12): 1136-1146.

190 Nelson PT*, De Planell-Saguer M, Lamprinaki S, Kiriakidou M, Zhang P, O'Doherty U, Mourelatos Z. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA. 2007 Oct;13(10):1787-92.

191 Nelson PT*, Keller JN.  RNA in brain disease: no longer just "the messenger in the middle". J Neuropathol Exp Neurol. 2007 Jun;66(6):461-8.

192 Kiriakidou M, Tan GS, Lamprinaki S, De Planell-Saguer M, Nelson PT, Mourelatos Z. An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell. 2007 Jun 15;129(6):1141-51.

193 Wilfred BR, Wang WX, Nelson PT*.  Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways.  Mol Genet Metab. 2007 Jul;91(3):209-17.

194 Nelson PT, Zhang PJ, Spagnoli GC, Tomaszewski JE, Pasha TL, Frosina D, Caballero OL, Simpson AJ, Old LJ, Jungbluth AA.  Cancer/testis (CT) antigens are expressed in fetal ovary.  Cancer Immun. 2007 Jan 12;7:1.

195 Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z.  RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain, RNA. 2006 12(2):187-91.

196 Kiriakidou, M, Nelson P, Lamprinaki S, Sharma A, and Mourelatos Z, Detection of microRNAs and Assays to Monitor microRNAs activities in vivo and in vitro Methods in Molecular Biology, Humana Press, 2005 309: 295-310.

197 Macnamara, KC, Chua, MM, Nelson PT, Shen H, Weiss, SR, Increased epitope-specific CD8+ Tcells prevent murine coronavirus spread to the spinal cord and subsequent demyelination.  Journal of Virology, 2005 79(6): 3370-3381.

198 Nelson PT, Baldwin DA, Scearce, LM, Oberholtzer, JC, Tobias JW, Mourelatos Z, A novel method for microarray-based, high-throughput, gene expression profiling of microRNAs.  Nature Methods, 2004 1: 155-161.

199 Evans SM, Judy KD, Dunphy I, Jenkins WT Hwang W-T, Nelson PT, Lustig R, Magarelli DP, Judkins AR, Collins R, Koch, CJ, Hypoxia is important in the biology and aggression of human glial brain tumors.  Clinical Cancer Research, 2004 10(24): 8177-84.

200 Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, Hatzigeorgiou A. A combined computational-experimental approach predicts human microRNA targets.  Genes Dev. 2004 18(10): 1165-78. 

201 Huang, JH, Simon, SL, Nagpal, S, Nelson, PT and Zager, EL. Management of Patients with Schwannomatosis: Report of Six Cases and Review of the Literature, Surgical Neurology 2004, 62(4): 353-361.

202 Jacobs DA, Liu GT, Nelson PT, Galetta SL.  Primary central nervous system angiitis, amyloid angiopathy, and Alzheimer's pathology presenting with Balint's syndrome.  Surv Ophthalmol. 2004 49(4):454-9

203 Nelson PT, Hatzigeorgiou AG, Mourelatos Z miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA. 2004 10(3): 387-94

204 Evans SM, Judy KD, Dunphy I, Jenkins WT, Nelson PT, Collins R, Wileyto EP, Jenkins K, Hahn SM, Stevens CW, Judkins AR, Phillips P, Geoerger B, Koch CJ. Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding.  Cancer Res. 2004 64(5): 1886-92.

205 Nelson, P, Kiriakidou, M, Sharma, A, Maniataki, E, Mourelatos, Z, The microRNA world: small is mighty", Trends in Bioch Sci 28(10) 2003: 534-540.

206 Van Deerlin VM, Gill LH, Nelson PT.  Optimizing gene expression analysis in archival brain tissue.  Neurochem Res. 2002  27: 993-1003.

207 Nelson PT, Soma LA, Lavi E.  Microglia in diseases of the central nervous system.  Ann Med. 2002; 34:491-500.

208 Goldsmith JD, Pawel B, Goldblum JR, Pasha TL, Roberts S, Nelson P, Khurana JS, Barr FG, Zhang PJ.  Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation.  Am J Surg Pathol. 2002 26: 1627-33.

209 Nelson PT, Kondziolka D, Wechsler L, Goldstein S, Gebel J, DeCesare S, Elder EM, Zhang PJ, Jacobs A, McGrogan M, Lee VM, Trojanowski JQ.  Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.  Am J Pathol. 2002;160:1201-6.

210 Nelson PT, Stefansson K, Gulcher J, Saper CB. Molecular evolution of tau protein: implications for Alzheimer's disease.  J Neurochem. 1996; 67:1622-32.

211 Nelson PT, Saper CB.  Injections of okadaic acid, but not beta-amyloid peptide, induce Alz-50 immunoreactive dystrophic neurites in the cerebral cortex of sheep. Neurosci Lett. 1996; 208:77-80.

212 Nelson PT, Saper CB.  Ultrastructure of neurofibrillary tangles in the cerebral cortex of sheep. Neurobiol Aging. 1995; 16:315-23.

213 Nelson PT, Greenberg SG, Saper CB. Neurofibrillary tangles in the cerebral cortex of sheep. Neurosci Lett. 1994; 170:187-90.

214 Nelson PT, Marton L, Saper CB.  Alz-50 immunohistochemistry in the normal sheep striatum: a light and electron microscope study. Brain Res. 1993; 600:285-97.

Book and Book Chapters

1     "Nelson, PT and Neltner, J.H., Pathology of Brain aging (Chapter 1), in Neurodegeneration, Eds--Anthony Schapira MD, DSc, FRCP, FMedSci, Zbigniew Wszolek MD, Ted M. Dawson MD, PhD and Nicholas Wood FRCP, PhD, FMedSci, 2017 John Wiley and Sons.

2     Pruzin, JJ, Nelson, PT, Abner, EL, Arvanitakis, Z.  Neuropathological Insights Into the Link Between Type 2 Diabetes and Dementia (Chapter 6) in Type 2 Diabetes and Dementia